Nirmal K. Chaudhary, Daniel Vuong, Ernest Lacey, Andrew M. Piggott and Peter Karuso*,
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Phenalenones and Polyesters from Talaromyces stipitatus and Structure Revision of Talaromycesone A
Investigation of the secondary metabolites of the filamentous fungus Talaromyces stipitatus led to the isolation of two new phenalenone dimers, talarohemiketal A (1) and talaroazasone A (2), and one new macrolide polyester, talaromacrolactone A (3), along with the reported oxyphenalenone dimers talaromycesone A (4), bacillisporin A (5), bacillisporin B (6), bacillisporin C (7), epi-bacillisporin F (8), and bacillisporin J (9), the phenalenone monomer funalenone (10), the polyesters 15G256α (11) and 15G256ν (12), and 6-hydroxymellein (13). Detailed analysis of 2D NMR correlations, supported by TDDFT calculations, led to the structural revision of talaromycesone A as 4 from previously reported structure 14. In addition, the previously misassigned NMR spectra of compound 8 have been corrected.
期刊介绍：
The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
When new compounds are reported, manuscripts describing their biological activity are much preferred.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
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