{"title":"转座因子甲基化与年龄有关。","authors":"Bernadette Hotzi, Tibor Vellai","doi":"10.1038/s43587-025-00807-3","DOIUrl":null,"url":null,"abstract":"In mammals, the 5-methylcytosine epigenetic mark is mostly located in transposable elements, which are repetitive intragenomic parasites. In this issue of Nature Aging, Gorbunova and colleagues show that 5-methylcytosine levels in certain LINE1 retrotransposon loci highly correlate with age and the incidence of certain pathologies. Thus, LINE1 (the only known transposable element family capable of autonomous jumping in the human genome) serves as a suitable DNA template for accurately determining age and predicting disease.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 2","pages":"179-181"},"PeriodicalIF":17.0000,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Transposable element methylation tracks age\",\"authors\":\"Bernadette Hotzi, Tibor Vellai\",\"doi\":\"10.1038/s43587-025-00807-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In mammals, the 5-methylcytosine epigenetic mark is mostly located in transposable elements, which are repetitive intragenomic parasites. In this issue of Nature Aging, Gorbunova and colleagues show that 5-methylcytosine levels in certain LINE1 retrotransposon loci highly correlate with age and the incidence of certain pathologies. Thus, LINE1 (the only known transposable element family capable of autonomous jumping in the human genome) serves as a suitable DNA template for accurately determining age and predicting disease.\",\"PeriodicalId\":94150,\"journal\":{\"name\":\"Nature aging\",\"volume\":\"5 2\",\"pages\":\"179-181\"},\"PeriodicalIF\":17.0000,\"publicationDate\":\"2025-01-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature aging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s43587-025-00807-3\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature aging","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s43587-025-00807-3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
In mammals, the 5-methylcytosine epigenetic mark is mostly located in transposable elements, which are repetitive intragenomic parasites. In this issue of Nature Aging, Gorbunova and colleagues show that 5-methylcytosine levels in certain LINE1 retrotransposon loci highly correlate with age and the incidence of certain pathologies. Thus, LINE1 (the only known transposable element family capable of autonomous jumping in the human genome) serves as a suitable DNA template for accurately determining age and predicting disease.
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