{"title":"衰老细胞免疫监测中的GD3神经节苷脂检查点。","authors":"Julia Majewska, Valery Krizhanovsky","doi":"10.1038/s43587-025-00803-7","DOIUrl":null,"url":null,"abstract":"Iltis, Moskalevska and colleagues investigate how the innate immune system regulates the age-related accumulation of senescent cells. They show that upregulation of the GD3 ganglioside-based immune checkpoint enables senescent cells to evade immune surveillance mediated by natural killer cells during aging, and that targeting GD3 is protective in age-related disease.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 2","pages":"182-183"},"PeriodicalIF":17.0000,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"GD3 ganglioside checkpoints in immune surveillance of senescent cells\",\"authors\":\"Julia Majewska, Valery Krizhanovsky\",\"doi\":\"10.1038/s43587-025-00803-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Iltis, Moskalevska and colleagues investigate how the innate immune system regulates the age-related accumulation of senescent cells. They show that upregulation of the GD3 ganglioside-based immune checkpoint enables senescent cells to evade immune surveillance mediated by natural killer cells during aging, and that targeting GD3 is protective in age-related disease.\",\"PeriodicalId\":94150,\"journal\":{\"name\":\"Nature aging\",\"volume\":\"5 2\",\"pages\":\"182-183\"},\"PeriodicalIF\":17.0000,\"publicationDate\":\"2025-01-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature aging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s43587-025-00803-7\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature aging","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s43587-025-00803-7","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
GD3 ganglioside checkpoints in immune surveillance of senescent cells
Iltis, Moskalevska and colleagues investigate how the innate immune system regulates the age-related accumulation of senescent cells. They show that upregulation of the GD3 ganglioside-based immune checkpoint enables senescent cells to evade immune surveillance mediated by natural killer cells during aging, and that targeting GD3 is protective in age-related disease.
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