以两亲性纳米淀粉为基质，超声处理制备的生育三烯醇纳米乳液的稳定性研究。

IF 3.3 2区农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY

Journal of the Science of Food and Agriculture Pub Date : 2025-01-17 DOI:10.1002/jsfa.14120

Gitanjali Gautam, Charu Lata Mahanta

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引用次数: 0

摘要

背景：辛烯基丁二酸酐（OSA）是食品工业中常用的高效乳化剂之一。目前的研究描述了通过将其与OSA结合然后将其转化为纳米乳来提高生育三烯醇（T3）的生物利用度。制备纳米乳ASG-T3U10、ASG-T3U20和ASG-T3U30时，超声功率为300 W，分别进行10次、20次和30次循环。结果：ASG-T3U30、ASG-T3U20和ASG-T3U10纳米乳粒径分别为100 ~ 200nm、200 ~ 300nm和> 300nm (p30)，在模拟胃肠环境中具有较好的包封效率和潜在稳定性。利用零阶模型、Higuchi模型、Korsmeyer-Peppas模型、Peppas-Sahlin模型和Gompertz模型等进行了释放动力学研究。这些模型与两亲性淀粉基质在胃肠道环境中释放T3的情况吻合良好（R2 > 0.90）。贮存稳定性试验表明，乳剂在4℃条件下贮存21天稳定，但14天后，粒径大于200 nm的乳剂开始出现奥斯特瓦尔德成熟。结论：研究表明，增加超声循环次数可有效增强纳米乳的稳定性。©2025化学工业协会。

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Enhancing the stability of tocotrienol nanoemulsion developed using ultrasonic treatment with amphiphilic starch nanoparticles serving as the matrix.

Background: Octenylsuccinic anhydride (OSA) is one of the efficient compounds used in food industries as an emulsifier. The current study describes the augmentation of tocotrienol (T3) bioavailability by combining it with OSA and then converting it into a nanoemulsion. The creation of the nanoemulsions ASG-T3U₁₀, ASG-T3U₂₀ and ASG-T3U₃₀ involved ultrasonication power at 300 W for 10, 20 and 30 cycles, respectively.

Result: The nanoemulsion particle sizes of ASG-T3U₃₀, ASG-T3U₂₀ and ASG-T3U₁₀ ranged from 100 to 200, 200 to 300 and >300 nm (P < 0.05), respectively. ASG-T3U₃₀ exhibited enhanced encapsulation efficiency and potential stability in a simulated gastrointestinal environment. A range of models such as zero order, Higuchi, Korsmeyer-Peppas, Peppas-Sahlin and Gompertz were utilized for the study of release kinetics. The models were found to be a good fit (R² > 0.90) for the release of T3 in the gastrointestinal environment from an amphiphilic starch matrix. Storage stability tests showed that the emulsions were stable for 21 days of storage at 4 °C, but after 14 days, samples with particle diameters greater than 200 nm displayed the onset of Ostwald ripening.

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来源期刊

Journal of the Science of Food and Agriculture 工程技术-农业综合

CiteScore

8.10

自引率

4.90%

发文量

634

审稿时长

3.1 months

期刊介绍： The Journal of the Science of Food and Agriculture publishes peer-reviewed original research, reviews, mini-reviews, perspectives and spotlights in these areas, with particular emphasis on interdisciplinary studies at the agriculture/ food interface. Published for SCI by John Wiley & Sons Ltd. SCI (Society of Chemical Industry) is a unique international forum where science meets business on independent, impartial ground. Anyone can join and current Members include consumers, business people, environmentalists, industrialists, farmers, and researchers. The Society offers a chance to share information between sectors as diverse as food and agriculture, pharmaceuticals, biotechnology, materials, chemicals, environmental science and safety. As well as organising educational events, SCI awards a number of prestigious honours and scholarships each year, publishes peer-reviewed journals, and provides Members with news from their sectors in the respected magazine, Chemistry & Industry . Originally established in London in 1881 and in New York in 1894, SCI is a registered charity with Members in over 70 countries.