肌源性肌肉生长抑制素是促卵泡激素合成的主要内分泌驱动因子

IF 44.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2025-01-16 DOI:10.1126/science.adi4736

Luisina Ongaro, Xiang Zhou, Ying Wang, Hailey Schultz, Ziyue Zhou, Evan R. S. Buddle, Emilie Brûlé, Yeu-Farn Lin, Gauthier Schang, Adam Hagg, Roselyne Castonguay, Yewei Liu, Gloria H. Su, Nabil G. Seidah, Kevin C. Ray, Seth J. Karp, Ulrich Boehm, Frederique Ruf-Zamojski, Stuart C. Sealfon, Kelly L. Walton, Se-Jin Lee, Daniel J. Bernard

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引用次数: 0

摘要

肌生长抑制素是一种调节包括人类在内的多种物种肌肉质量的旁分泌性肌肉因子。在这项工作中，我们报道了肌生长抑制素作为一种内分泌激素的功能作用，直接促进垂体促卵泡激素（FSH）的合成，从而促进小鼠卵巢功能。以前，这种刺激fsh的作用归因于转化生长因子-β家族的其他成员，即激活素。我们的研究结果既挑战了激活素在FSH合成中的作用，也在骨骼肌和脑垂体之间建立了一个意想不到的内分泌轴。我们的数据还表明，对抗肌肉生长抑制素以增加肌肉质量的努力可能会对生育能力产生意想不到的后果。

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Muscle-derived myostatin is a major endocrine driver of follicle-stimulating hormone synthesis

Myostatin is a paracrine myokine that regulates muscle mass in a variety of species, including humans. In this work, we report a functional role for myostatin as an endocrine hormone that directly promotes pituitary follicle-stimulating hormone (FSH) synthesis and thereby ovarian function in mice. Previously, this FSH-stimulating role was attributed to other members of the transforming growth factor–β family, the activins. Our results both challenge activin’s eponymous role in FSH synthesis and establish an unexpected endocrine axis between skeletal muscle and the pituitary gland. Our data also suggest that efforts to antagonize myostatin to increase muscle mass may have unintended consequences on fertility.

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来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

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