SIRT3在心血管和神经退行性疾病中的作用。

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2025-02-01 DOI:10.1016/j.arr.2024.102654

Yu Cheng , Anqi Zhao , Ying Li , Cheng Li , Xiao Miao , Wanshan Yang , Yonggang Wang

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引用次数: 0

摘要

线粒体中的Sirtuin-3 （SIRT3）具有烟酰胺腺嘌呤二核苷酸（NAD+）依赖的蛋白去乙酰化酶活性。因此，SIRT3在心血管和神经退行性疾病中至关重要。先进的蛋白质组学和转录组学研究表明，当心脏或大脑受到外部刺激或疾病（如糖尿病性心肌病、动脉粥样硬化、心肌梗死、阿尔茨海默病、亨廷顿病和帕金森病）的影响时，SIRT3的表达会发生改变。更具体地说，SIRT3通过其去乙酰化酶活性和与下游信号通路的结合参与了这些疾病的发展。本文就SIRT3在心血管和神经退行性疾病中的表达变化、作用及其机制进行综述。此外，还讨论了靶向SIRT3治疗或调节心血管和神经退行性疾病发展的策略。

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Roles of SIRT3 in cardiovascular and neurodegenerative diseases

Sirtuin-3 (SIRT3) in mitochondria has nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylase activity. As such, SIRT3 is crucial in cardiovascular and neurodegenerative diseases. Advanced proteomics and transcriptomics studies have revealed that SIRT3 expression becomes altered when the heart or brain is affected by external stimuli or disease, such as diabetic cardiomyopathy, atherosclerosis, myocardial infarction, Alzheimer's disease, Huntington's disease, and Parkinson's disease. More specifically, SIRT3 participates in the development of these disorders through its deacetylase activity and in combination with downstream signaling pathways. The paper reviews SIRT3’s expression changes, roles, and mechanisms associated with the development of cardiovascular and neurodegenerative diseases. Additionally, strategies targeting SIRT3 to treat or regulate cardiovascular and neurodegenerative disease development are discussed.

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.