2013 - 2021年法国某大学医院产碳青霉烯酶肠杆菌（CPE）的流行病学和细菌学趋势：爆发的永久性风险

IF 2.9 4区医学 Q2 INFECTIOUS DISEASES

Infectious diseases now Pub Date : 2025-02-01 DOI:10.1016/j.idnow.2024.105021

Manon Robert , Stéphane Corvec , Anaïs Andreo , Florence Le Gallou , Géraldine Marquot , Reynald Mangeant , Céline Bourigault , Didier Lepelletier

{"title":"2013 - 2021年法国某大学医院产碳青霉烯酶肠杆菌（CPE）的流行病学和细菌学趋势：爆发的永久性风险","authors":"Manon Robert , Stéphane Corvec , Anaïs Andreo , Florence Le Gallou , Géraldine Marquot , Reynald Mangeant , Céline Bourigault , Didier Lepelletier","doi":"10.1016/j.idnow.2024.105021","DOIUrl":null,"url":null,"abstract":"<div><h3>Aim</h3><div>The aim of this study was to describe the epidemiology and bacteriological trends of carbapenemase-producing Enterobacteriaceae (CPE) at Nantes University Hospital from 2013 to 2023.</div></div><div><h3>Methods</h3><div>Potential CPE carriers were prospectively detected, and their contacts were systematically screened for CPE digestive colonization. A retrospective study was conducted from 2013 to 2023 (on patient characteristics) and from 2016 to 2023 (on CPE characteristics). An outbreak was defined as at least one secondary case occurring among contact patients during the same hospitalization, in the same unit, and with the same staff.</div></div><div><h3>Results</h3><div>All in all, 553 CPE-positive carriers were identified during the study period. Among them, 178 (32 %) were sporadic cases and 100 (18 %) were incidentally detected. Fifty-seven outbreaks were investigated comprising 305 (55 %) secondary cases. The most commonly identified CPE species in outbreaks were Klebsiella pneumonia OXA-48.</div></div><div><h3>Conclusion</h3><div>CPE detection in the hospital was associated mainly with epidemic spread involving a variable number of secondary cases. CPE patients detected incidentally (without specific infection control measures) several days after hospital admission, repatriates and patients with a history of hospitalization abroad are at high risk of in-hospital CPE spread. The number of outbreaks did not decrease during the study period, and more generally, the number of secondary cases tends in some uncontrolled situations to increase, particular when CPE- positive patients are transferred or rehospitalized.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 1","pages":"Article 105021"},"PeriodicalIF":2.9000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Epidemiological and bacteriological trends from 2013 to 2023 of carbapenemase-producing enterobacterales (CPE) in a French university hospital: A permanent risk of outbreak\",\"authors\":\"Manon Robert , Stéphane Corvec , Anaïs Andreo , Florence Le Gallou , Géraldine Marquot , Reynald Mangeant , Céline Bourigault , Didier Lepelletier\",\"doi\":\"10.1016/j.idnow.2024.105021\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Aim</h3><div>The aim of this study was to describe the epidemiology and bacteriological trends of carbapenemase-producing Enterobacteriaceae (CPE) at Nantes University Hospital from 2013 to 2023.</div></div><div><h3>Methods</h3><div>Potential CPE carriers were prospectively detected, and their contacts were systematically screened for CPE digestive colonization. A retrospective study was conducted from 2013 to 2023 (on patient characteristics) and from 2016 to 2023 (on CPE characteristics). An outbreak was defined as at least one secondary case occurring among contact patients during the same hospitalization, in the same unit, and with the same staff.</div></div><div><h3>Results</h3><div>All in all, 553 CPE-positive carriers were identified during the study period. Among them, 178 (32 %) were sporadic cases and 100 (18 %) were incidentally detected. Fifty-seven outbreaks were investigated comprising 305 (55 %) secondary cases. The most commonly identified CPE species in outbreaks were Klebsiella pneumonia OXA-48.</div></div><div><h3>Conclusion</h3><div>CPE detection in the hospital was associated mainly with epidemic spread involving a variable number of secondary cases. CPE patients detected incidentally (without specific infection control measures) several days after hospital admission, repatriates and patients with a history of hospitalization abroad are at high risk of in-hospital CPE spread. The number of outbreaks did not decrease during the study period, and more generally, the number of secondary cases tends in some uncontrolled situations to increase, particular when CPE- positive patients are transferred or rehospitalized.</div></div>\",\"PeriodicalId\":13539,\"journal\":{\"name\":\"Infectious diseases now\",\"volume\":\"55 1\",\"pages\":\"Article 105021\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2025-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Infectious diseases now\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S266699192400188X\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infectious diseases now","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S266699192400188X","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

摘要

目的：研究2013 - 2023年南特大学医院产碳青霉烯酶肠杆菌科（CPE）的流行病学及细菌学趋势。方法：前瞻性检测潜在的CPE携带者，系统筛选其接触者进行CPE消化定植。回顾性研究于2013年至2023年（患者特征）和2016年至2023年（CPE特征）进行。暴发定义为在同一住院期间、同一单位和同一工作人员接触的接触者中至少发生一例继发性病例。结果：研究期间共检出553例cpe阳性携带者。散发病例178例（32 %），偶然发现病例100例（18 %）。调查了57次暴发，包括305例（55% %）继发病例。暴发中最常见的CPE物种是肺炎克雷伯菌OXA-48。结论：医院CPE的检出主要与流行传播有关，继发病例数量不定。入院数天后偶然发现（无特定感染控制措施）的CPE患者、遣返者和有国外住院史的患者是院内CPE传播的高危人群。在研究期间，暴发的数量并没有减少，更普遍的是，在一些不受控制的情况下，继发病例的数量趋于增加，特别是当CPE阳性患者被转移或再住院时。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Epidemiological and bacteriological trends from 2013 to 2023 of carbapenemase-producing enterobacterales (CPE) in a French university hospital: A permanent risk of outbreak

Aim

The aim of this study was to describe the epidemiology and bacteriological trends of carbapenemase-producing Enterobacteriaceae (CPE) at Nantes University Hospital from 2013 to 2023.

Methods

Potential CPE carriers were prospectively detected, and their contacts were systematically screened for CPE digestive colonization. A retrospective study was conducted from 2013 to 2023 (on patient characteristics) and from 2016 to 2023 (on CPE characteristics). An outbreak was defined as at least one secondary case occurring among contact patients during the same hospitalization, in the same unit, and with the same staff.

Results

All in all, 553 CPE-positive carriers were identified during the study period. Among them, 178 (32 %) were sporadic cases and 100 (18 %) were incidentally detected. Fifty-seven outbreaks were investigated comprising 305 (55 %) secondary cases. The most commonly identified CPE species in outbreaks were Klebsiella pneumonia OXA-48.

Conclusion

CPE detection in the hospital was associated mainly with epidemic spread involving a variable number of secondary cases. CPE patients detected incidentally (without specific infection control measures) several days after hospital admission, repatriates and patients with a history of hospitalization abroad are at high risk of in-hospital CPE spread. The number of outbreaks did not decrease during the study period, and more generally, the number of secondary cases tends in some uncontrolled situations to increase, particular when CPE- positive patients are transferred or rehospitalized.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊