将抗焦虑作用与海马体“θ”联系起来——个人历史

IF 2.4 3区医学 Q3 NEUROSCIENCES

Hippocampus Pub Date : 2024-12-20 DOI:10.1002/hipo.23653

N. McNaughton

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引用次数: 0

摘要

本文提供了个人的工作历史，从发现抗焦虑药物减少海马theta频率开始。它包括在牛津的杰弗里·格雷（Jeffrey Gray）实验室进行的关于脑隔激发的平行研究；我对这项工作的原始科学观点的陈述；以及我后来在新西兰实验室的工作描述，证实了θ节律性本身的功能，以及它对抗焦虑药物对行为的影响的中介作用。最后，我对此类实验的风险管理及其在更大规模理论发展中的应用进行了评论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Linking Anxiolytic Action to Hippocampal “Theta”—A Personal History

This paper provides a personal history of work starting with the discovery that anxiolytic drugs reduce hippocampal theta frequency. It includes parallel work on septal elicitation of theta carried out in Jeffrey Gray's laboratory in Oxford; a statement of my original scientific perspective on the work; and a description of later work in my laboratory in New Zealand confirming the function of theta rhythmicity per se and its mediation of the effects of anxiolytic drugs on behavior. I finish with comments on risk management with such experiments and their use in larger scale theory development.

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来源期刊

Hippocampus 医学-神经科学

CiteScore

5.80

自引率

5.70%

发文量

审稿时长

3-8 weeks

期刊介绍： Hippocampus provides a forum for the exchange of current information between investigators interested in the neurobiology of the hippocampal formation and related structures. While the relationships of submitted papers to the hippocampal formation will be evaluated liberally, the substance of appropriate papers should deal with the hippocampal formation per se or with the interaction between the hippocampal formation and other brain regions. The scope of Hippocampus is wide: single and multidisciplinary experimental studies from all fields of basic science, theoretical papers, papers dealing with hippocampal preparations as models for understanding the central nervous system, and clinical studies will be considered for publication. The Editor especially encourages the submission of papers that contribute to a functional understanding of the hippocampal formation.