IF 4.4 2区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Maryam Nagib, Ahmed M Sayed, Ahmed H Korany, Karim Abdelkader, Falah H Shari, William G Mackay, Mostafa E Rateb
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引用次数: 0

摘要

人类防御素是一组阳离子抗菌肽,大小在 2 到 5 kDa 之间,具有六个二硫键连接半胱氨酸的共同结构基团。在过去二十年中,已经发现了几种天然存在的人类α-和β-防御素。它们具有多种抗菌作用,而且具有避免对抗菌治疗产生抗药性的潜力,因此可作为治疗药物。由于人类防御素在医学和制药业中的应用前景广阔,它们最近成为医学和分子生物学研究的焦点。本研究旨在全面总结人类防御素的当前发展情况,包括其识别、分类、分子特征、表达、作用模式以及在医疗环境中的潜在应用。此外,还介绍了目前使用人类防御素的障碍和未来机遇。此外,我们还对人类防御素的合理作用机制进行了基于硅学的研究,从而揭示了人类防御素作为抗病毒药物的潜力,尤其是抗 SARS CoV-2 的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Human Defensins: Structure, Function, and Potential as Therapeutic Antimicrobial Agents with Highlights Against SARS CoV-2.

The human defensins are a group of cationic antimicrobial peptides that range in size from 2 to 5 kDa and share a common structural motif of six disulphide-linked cysteines. Several naturally occurring human α- and β-defensins have been identified over the past two decades. They have a wide variety of antimicrobial effects, and their potential to avoid the development of resistance to antimicrobial treatment makes them attractive as therapeutic agents. Human defensins have recently been the focus of medical and molecular biology studies due to their promising application in medicine and the pharmaceutical industry. This work aims to provide a comprehensive summary of the current developments of human defensins, including their identification, categorization, molecular features, expression, modes of action, and potential application in medical settings. Current obstacles and future opportunities for using human defensins are also covered. Furthermore, we shed light on the potential of this class as an antiviral agent, particularly against SARS CoV-2, by providing an in silico-based investigation of their plausible mechanisms of action.

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来源期刊
Probiotics and Antimicrobial Proteins
Probiotics and Antimicrobial Proteins BIOTECHNOLOGY & APPLIED MICROBIOLOGYMICROB-MICROBIOLOGY
CiteScore
11.30
自引率
6.10%
发文量
140
期刊介绍: Probiotics and Antimicrobial Proteins publishes reviews, original articles, letters and short notes and technical/methodological communications aimed at advancing fundamental knowledge and exploration of the applications of probiotics, natural antimicrobial proteins and their derivatives in biomedical, agricultural, veterinary, food, and cosmetic products. The Journal welcomes fundamental research articles and reports on applications of these microorganisms and substances, and encourages structural studies and studies that correlate the structure and functional properties of antimicrobial proteins.
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