Alina von Etzdorf, Maja Harzen, Hannah Heinrichs, Henning Seifert, Stefan J Groiß, Carolin Balloff, Torsten Feldt, Björn-Erik Ole Jensen, Tom Lüdde, Michael Bernhard, Alfons Schnitzler, Klaus Goebels, Jörg Kraus, Sven G Meuth, Saskia Elben, Philipp Albrecht
{"title":"基于人群的 SARS-CoV-2 患者认知测试 (POPCOV2) 研究：对 PCR 阳性病例和阴性对照组进行远程认知和疲劳筛查的纵向调查。","authors":"Alina von Etzdorf, Maja Harzen, Hannah Heinrichs, Henning Seifert, Stefan J Groiß, Carolin Balloff, Torsten Feldt, Björn-Erik Ole Jensen, Tom Lüdde, Michael Bernhard, Alfons Schnitzler, Klaus Goebels, Jörg Kraus, Sven G Meuth, Saskia Elben, Philipp Albrecht","doi":"10.3389/fnhum.2024.1468204","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The majority of people infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) only show mild respiratory symptoms. However, some patients with SARS-CoV-2 display neurological symptoms. Data on the exact prevalence and course of cognitive symptoms are often limited to patient reported outcomes or studies recruited at specialized centers.</p><p><strong>Methods: </strong>For this prospective, non-interventional population based POPCOV2 study, 156 subjects who performed SARS-CoV-2 testing in the Düsseldorf metropolitan area at public test centers between December 2020 and February 2022 were recruited by handouts. SARS-CoV-2-positive and negatively tested subjects were included within the first seven days after the PCR test results. Cognitive testing was performed at baseline during home quarantine and after 4-6 as well as 12-14 weeks of follow-up. Individuals were examined remotely by videocalls using the Symbol Digit Modalities Test (SDMT) and the Montreal Cognitive Assessment (MoCA) in addition to the Brief Fatigue Inventory (BFI) and the Beck Depression Inventory-Fast Screen (BDI-FS).</p><p><strong>Results: </strong>At baseline, the SARS-CoV-2-positive group presented with higher levels of fatigue in the BFI. In both the SARS-CoV-2-positive and SARS-CoV-2-negative groups, some subjects presented attention and memory deficits, defined as a z-score < -1,65 on the SDMT or < 26 points on the MoCA (SDMT: 22.9% in the positive and 8.8% in the negative group, <i>p</i> = 0.024; MoCA: 35.6% in the positive and 27.3% in the negative group, <i>p</i> = 0.313). MoCA and SDMT improved over time in both groups. For MoCA scores, a significant difference between the two groups was only seen at the first follow-up. SDMT z-scores did not differ at any time between the groups.</p><p><strong>Conclusion: </strong>These results support previous evidence that mild SARS-CoV-2 infections are associated with increased fatigue. However, we found relevant rates of cognitive impairment not only in the infected but also in the control group. This underlines the importance of including a control group in such investigations.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"18 ","pages":"1468204"},"PeriodicalIF":2.4000,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11638161/pdf/","citationCount":"0","resultStr":"{\"title\":\"The population based cognitive testing in subjects with SARS-CoV-2 (POPCOV2) study: longitudinal investigation of remote cognitive and fatigue screening in PCR-positive cases and negative controls.\",\"authors\":\"Alina von Etzdorf, Maja Harzen, Hannah Heinrichs, Henning Seifert, Stefan J Groiß, Carolin Balloff, Torsten Feldt, Björn-Erik Ole Jensen, Tom Lüdde, Michael Bernhard, Alfons Schnitzler, Klaus Goebels, Jörg Kraus, Sven G Meuth, Saskia Elben, Philipp Albrecht\",\"doi\":\"10.3389/fnhum.2024.1468204\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The majority of people infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) only show mild respiratory symptoms. However, some patients with SARS-CoV-2 display neurological symptoms. Data on the exact prevalence and course of cognitive symptoms are often limited to patient reported outcomes or studies recruited at specialized centers.</p><p><strong>Methods: </strong>For this prospective, non-interventional population based POPCOV2 study, 156 subjects who performed SARS-CoV-2 testing in the Düsseldorf metropolitan area at public test centers between December 2020 and February 2022 were recruited by handouts. SARS-CoV-2-positive and negatively tested subjects were included within the first seven days after the PCR test results. Cognitive testing was performed at baseline during home quarantine and after 4-6 as well as 12-14 weeks of follow-up. Individuals were examined remotely by videocalls using the Symbol Digit Modalities Test (SDMT) and the Montreal Cognitive Assessment (MoCA) in addition to the Brief Fatigue Inventory (BFI) and the Beck Depression Inventory-Fast Screen (BDI-FS).</p><p><strong>Results: </strong>At baseline, the SARS-CoV-2-positive group presented with higher levels of fatigue in the BFI. In both the SARS-CoV-2-positive and SARS-CoV-2-negative groups, some subjects presented attention and memory deficits, defined as a z-score < -1,65 on the SDMT or < 26 points on the MoCA (SDMT: 22.9% in the positive and 8.8% in the negative group, <i>p</i> = 0.024; MoCA: 35.6% in the positive and 27.3% in the negative group, <i>p</i> = 0.313). MoCA and SDMT improved over time in both groups. For MoCA scores, a significant difference between the two groups was only seen at the first follow-up. SDMT z-scores did not differ at any time between the groups.</p><p><strong>Conclusion: </strong>These results support previous evidence that mild SARS-CoV-2 infections are associated with increased fatigue. However, we found relevant rates of cognitive impairment not only in the infected but also in the control group. This underlines the importance of including a control group in such investigations.</p>\",\"PeriodicalId\":12536,\"journal\":{\"name\":\"Frontiers in Human Neuroscience\",\"volume\":\"18 \",\"pages\":\"1468204\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2024-11-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11638161/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Human Neuroscience\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3389/fnhum.2024.1468204\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Human Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fnhum.2024.1468204","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
The population based cognitive testing in subjects with SARS-CoV-2 (POPCOV2) study: longitudinal investigation of remote cognitive and fatigue screening in PCR-positive cases and negative controls.
Background: The majority of people infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) only show mild respiratory symptoms. However, some patients with SARS-CoV-2 display neurological symptoms. Data on the exact prevalence and course of cognitive symptoms are often limited to patient reported outcomes or studies recruited at specialized centers.
Methods: For this prospective, non-interventional population based POPCOV2 study, 156 subjects who performed SARS-CoV-2 testing in the Düsseldorf metropolitan area at public test centers between December 2020 and February 2022 were recruited by handouts. SARS-CoV-2-positive and negatively tested subjects were included within the first seven days after the PCR test results. Cognitive testing was performed at baseline during home quarantine and after 4-6 as well as 12-14 weeks of follow-up. Individuals were examined remotely by videocalls using the Symbol Digit Modalities Test (SDMT) and the Montreal Cognitive Assessment (MoCA) in addition to the Brief Fatigue Inventory (BFI) and the Beck Depression Inventory-Fast Screen (BDI-FS).
Results: At baseline, the SARS-CoV-2-positive group presented with higher levels of fatigue in the BFI. In both the SARS-CoV-2-positive and SARS-CoV-2-negative groups, some subjects presented attention and memory deficits, defined as a z-score < -1,65 on the SDMT or < 26 points on the MoCA (SDMT: 22.9% in the positive and 8.8% in the negative group, p = 0.024; MoCA: 35.6% in the positive and 27.3% in the negative group, p = 0.313). MoCA and SDMT improved over time in both groups. For MoCA scores, a significant difference between the two groups was only seen at the first follow-up. SDMT z-scores did not differ at any time between the groups.
Conclusion: These results support previous evidence that mild SARS-CoV-2 infections are associated with increased fatigue. However, we found relevant rates of cognitive impairment not only in the infected but also in the control group. This underlines the importance of including a control group in such investigations.
期刊介绍：
Frontiers in Human Neuroscience is a first-tier electronic journal devoted to understanding the brain mechanisms supporting cognitive and social behavior in humans, and how these mechanisms might be altered in disease states. The last 25 years have seen an explosive growth in both the methods and the theoretical constructs available to study the human brain. Advances in electrophysiological, neuroimaging, neuropsychological, psychophysical, neuropharmacological and computational approaches have provided key insights into the mechanisms of a broad range of human behaviors in both health and disease. Work in human neuroscience ranges from the cognitive domain, including areas such as memory, attention, language and perception to the social domain, with this last subject addressing topics, such as interpersonal interactions, social discourse and emotional regulation. How these processes unfold during development, mature in adulthood and often decline in aging, and how they are altered in a host of developmental, neurological and psychiatric disorders, has become increasingly amenable to human neuroscience research approaches. Work in human neuroscience has influenced many areas of inquiry ranging from social and cognitive psychology to economics, law and public policy. Accordingly, our journal will provide a forum for human research spanning all areas of human cognitive, social, developmental and translational neuroscience using any research approach.
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