人均饮酒量与癌症死亡率之间是否存在联系?

IF 3 3区 医学 Q2 SUBSTANCE ABUSE
Iman Dadgar, Thor Norström, Mats Ramstedt
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引用次数: 0

摘要

导言:越来越多的证据表明,饮酒是越来越多癌症类型的致病因素,从而使饮酒成为全球癌症的主要风险因素。令人惊讶的是,尽管对公共健康有重大影响,但很少有研究探讨人口饮酒量的变化对癌症死亡率的影响程度。本文旨在:(i) 估计人均饮酒量的变化对癌症总死亡率和特定类型酒精相关癌症的影响;(ii) 评估癌症与人口饮酒量之间的关联是否受国家饮酒模式的影响:我们使用了 19 个高收入国家的时间序列数据,时间跨度为 1960-2018 年。卷烟销量和人均 GDP 被列为控制变量。数据采用一阶差分模型进行分析。世界卫生组织饮酒模式评分被用来评估一个国家的饮酒模式:我们的研究结果表明,人均饮酒量每增加 1 升,女性癌症总死亡率就会上升 0.9%,男性癌症总死亡率上升 1.1%。值得注意的是,在男性中,酒精效应证据确凿的癌症和前列腺癌的相关性更为明显。就女性而言,酒精对乳腺癌的影响在统计学上是显著的。一般来说,在饮酒模式较为有害的国家组中,酒精的估计效应较高:讨论与结论:我们的研究结果表明,降低人均酒精消费量有可能降低癌症死亡率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Is there a link between per capita alcohol consumption and cancer mortality?

Is there a link between per capita alcohol consumption and cancer mortality?

Introduction

A growing body of evidence has established alcohol consumption as a causative factor in an increasing array of cancer types, thereby positioning it as a leading global risk factor for cancer. Surprisingly, there is a scarcity of studies examining the extent to which shifts in population drinking affect cancer mortality, despite the substantial public health implications. This paper aims to: (i) estimate the impact of changes in per capita alcohol consumption on both overall cancer mortality rates and specific types of alcohol-related cancer; and (ii) assess whether the association between cancer and population alcohol consumption is influenced by a country's drinking patterns.

Methods

We used time-series data for 19 high-income countries spanning the period 1960–2018. Cigarette sales and GDP per capita were included as control variables. The data were analysed using first-difference modelling. The World Health Organization drinking patterns score was used to evaluate a country's drinking pattern.

Results

Our findings revealed that a 1 L per capita increase in alcohol consumption was associated with a 0.9% rise in total cancer mortality among women and a 1.1% increase among men. Notably, among men, the association was more pronounced for cancers with strong evidence of alcohol's effect and for prostate cancer. For women, the alcohol effect was statistically significant for breast cancer. Generally, the estimated alcohol effects were elevated in the country group with more harmful drinking patterns.

Discussion and Conclusions

Our results indicate that lowering per capita alcohol consumption is likely to reduce cancer mortality.

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来源期刊
Drug and alcohol review
Drug and alcohol review SUBSTANCE ABUSE-
CiteScore
4.80
自引率
10.50%
发文量
151
期刊介绍: Drug and Alcohol Review is an international meeting ground for the views, expertise and experience of all those involved in studying alcohol, tobacco and drug problems. Contributors to the Journal examine and report on alcohol and drug use from a wide range of clinical, biomedical, epidemiological, psychological and sociological perspectives. Drug and Alcohol Review particularly encourages the submission of papers which have a harm reduction perspective. However, all philosophies will find a place in the Journal: the principal criterion for publication of papers is their quality.
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