原花青素对甲状腺素诱导的衰老小鼠认知改善的影响。

IF 5.1 1区 农林科学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Food & Function Pub Date : 2024-12-09 DOI:10.1039/D4FO03987D
Chong Yuan, Hongtao Ren, Kexin Hu, Linlin Chen, Ke Yue, Kunmiao He, Qiuying Yu, Na Wang and Gaiping Zhang
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引用次数: 0

摘要

随着人口老龄化,功能性膳食补充剂越来越多地用于减少与年龄有关的疾病,特别是在认知障碍领域。本研究建立甲状腺素(Th)诱导的衰老模型,从认知能力、神经炎症和免疫水平等方面评价原花青素(Pc)对衰老小鼠认知功能损伤的影响。结果显示,与模型组相比,Pc显著降低了老龄小鼠乙酰胆碱酯酶活性,改善了老年小鼠的学习缺陷和空间记忆(P < 0.01)。进一步研究表明,Pc能维持机体氧化还原平衡,显著提高T-AOC、GSH和SOD水平(P < 0.01),降低MPO和MDA水平(P < 0.01)。Pc还能改善全身炎症,提高抗炎细胞因子PF4水平,显著降低血液中促炎因子(P < 0.01)。在海马DG区,Pc能有效修复神经损伤,抑制小胶质细胞和星形胶质细胞的过度激活,下调GFAP和IBA-1蛋白(P < 0.01),从而减轻神经炎症。此外,添加Pc还显著提高了老龄小鼠的WBC、Lymph、Mid和Gran水平(P < 0.01),有助于白细胞计数的恢复。同时显著提高衰老小鼠的CD3+水平和CD4+/CD8+比值(P < 0.01),维持衰老小鼠淋巴细胞亚群的动态平衡,增强衰老小鼠的免疫能力。研究表明,Pc作为一种膳食补充剂,可以有效缓解老年人群的认知功能障碍。这为老年人的健康提供了一种新的膳食营养补充策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Effect of proanthocyanidins on cognitive improvement in thyroxin-induced aging mice

Effect of proanthocyanidins on cognitive improvement in thyroxin-induced aging mice

As the population ages, functional dietary supplements are increasingly used to reduce age-related diseases, especially in the field of cognitive impairment. In this study, a thyroxine (Th)-induced aging model was established, and the effect of proanthocyanidins (Pc) on cognitive impairment of aging mice was evaluated based on cognitive ability, neuroinflammation and immune level. The results showed that Pc significantly reduced AchE activity compared to the Model group, improving learning deficits and spatial memory in aged mice (P < 0.01). Further study showed that Pc could maintain the organism's redox balance, markedly increasing T-AOC, GSH, and SOD levels (P < 0.01) while reducing MPO and MDA levels (P < 0.01). Pc also improved systemic inflammation, raising the levels of the anti-inflammatory cytokine PF4 and significantly lowering pro-inflammatory factors in the blood (P < 0.01). In the DG region of the hippocampus, Pc effectively repaired nerve damage, inhibited the over-activation of microglia and astrocytes, down-regulated GFAP and IBA-1 proteins (P < 0.01), and then reduced neuroinflammation. Additionally, Pc supplementation also significantly increased the levels of WBC, Lymph, Mid, and Gran in aged mice (P < 0.01), aiding in the recovery of leukocyte counts. At the same time, the CD3+ level and CD4+/CD8+ ratio were significantly increased (P < 0.01) to maintain the dynamic balance of lymphocyte subsets in aging mice and enhance the immune capacity of aging mice. The study revealed that Pc, as a dietary supplement, can effectively alleviate cognitive impairment in the elderly population. This provides a new dietary nutrition supplement strategy for the health of the aging population.

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来源期刊
Food & Function
Food & Function BIOCHEMISTRY & MOLECULAR BIOLOGY-FOOD SCIENCE & TECHNOLOGY
CiteScore
10.10
自引率
6.60%
发文量
957
审稿时长
1.8 months
期刊介绍: Food & Function provides a unique venue for physicists, chemists, biochemists, nutritionists and other food scientists to publish work at the interface of the chemistry, physics and biology of food. The journal focuses on food and the functions of food in relation to health.
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