具有独特免疫组化特征的青少年浅表cd34阳性纤维母细胞肿瘤。

IF 1.6 4区医学 Q3 DERMATOLOGY

Journal of Cutaneous Pathology Pub Date : 2024-12-05 DOI:10.1111/cup.14770

Scott Kuan-Wen Wang, Srinivas Mandavilli

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引用次数: 0

摘要

浅表cd34阳性纤维母细胞瘤（SCD34FT）是一种相对罕见的软组织肿瘤，于2014年首次被发现，并被纳入最新的第5版世界卫生组织软组织和骨肿瘤分类。显示PRDM10重排的scd34ft亚群可能与其他PRDM10重排的软组织肿瘤重叠，表明它们具有共同的致病途径。我们报告一例16岁的患者，是最年轻的确诊病例之一，前臂SCD34FT，具有PRDM10重排和细胞角蛋白（CK AE1/AE3）独特的弥漫性表达。该病例有助于扩大SCD34FT的文献，突出其临床和病理多样性。

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Adolescent Superficial CD34-Positive Fibroblastic Tumor With Unique IHC Profile

Superficial CD34-positive fibroblastic tumor (SCD34FT) is a relatively uncommon soft tissue neoplasm, first identified in 2014 and included in the latest, fifth edition of the World Health Organization Soft Tissue and Bone Tumors Classification. A subset of SCD34FTs that exhibit PRDM10 rearrangement may overlap with other PRDM10-rearranged soft tissue tumors, suggesting a shared pathogenic pathway. We report a case of a 16-year-old patient, one of the youngest diagnosed, with an SCD34FT on the forearm, featuring both PRDM10 rearrangement and a unique, diffuse expression of cytokeratin (CK AE1/AE3). This case contributes to the expanding literature on SCD34FT, highlighting its clinical and pathological diversity.

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来源期刊

Journal of Cutaneous Pathology 医学-病理学

CiteScore

3.20

自引率

5.90%

发文量

174

审稿时长

3-8 weeks

期刊介绍： Journal of Cutaneous Pathology publishes manuscripts broadly relevant to diseases of the skin and mucosae, with the aims of advancing scientific knowledge regarding dermatopathology and enhancing the communication between clinical practitioners and research scientists. Original scientific manuscripts on diagnostic and experimental cutaneous pathology are especially desirable. Timely, pertinent review articles also will be given high priority. Manuscripts based on light, fluorescence, and electron microscopy, histochemistry, immunology, molecular biology, and genetics, as well as allied sciences, are all welcome, provided their principal focus is on cutaneous pathology. Publication time will be kept as short as possible, ensuring that articles will be quickly available to all interested in this speciality.