阿尔茨海默病细胞外囊泡填充的microRNAs分析：病理和诊断之间的分子中介。

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2025-02-01 DOI:10.1016/j.arr.2024.102614

Sandila Arif , Talal Jamil Qazi , Zhenzhen Quan , Junjun Ni , Zhaohan Li , Yunjie Qiu , Hong Qing

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引用次数: 0

摘要

MicroRNAs （miRNAs）是一种参与多种生物过程的非编码rna，通过增加β淀粉样蛋白（a β）的产生、增强Tau磷酸化和诱导神经炎症参与阿尔茨海默病（AD）的病理生理。同时，细胞外囊泡（EVs）被认为是AD生物标志物的有希望的载体，因为它们具有将信息从脑组织传递到外周血的能力。受上述发现的启发，我们在这篇综述中系统地概括了miRNA在AD中的作用，并探讨了ev包装miRNA作为AD早期诊断的生物标志物的潜力。通过详细的研究，本综述可能会强调ev包装mirna在促进我们对AD的理解方面的前景，并强调进一步研究其诊断潜力的迫切需要。

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Extracellular vesicle-packed microRNAs profiling in Alzheimer’s disease: The molecular intermediary between pathology and diagnosis

MicroRNAs (miRNAs), referring to a type of non-coding RNAs functioning in various biological processes, participate in the pathophysiology of Alzheimer's disease (AD) through increasing amyloid-beta (Aβ) production, enhancing Tau phosphorylation, and inducing neuroinflammation. Meanwhile, extracellular vesicles (EVs) have been suggested as promising carriers of AD biomarkers as they possess the ability to transmit information from cerebral tissue to peripheral blood. Inspired by the above findings, we in this review systematically generalized the roles of miRNAs in AD and explored the potential of EV-packed miRNA as biomarkers for early diagnosis of AD. Through the detailed investigation, this review may highlight the promise of EV-packed miRNAs in advancing our understanding of AD, and underscore the imperative needs of further studies on their diagnostic potential.

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.