Maryam Sharifi, Amir Saber, Jalal Moludi, Yahya Salimi, Alireza Jahan-Mihan
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Thus, this study aimed to compare the impact of PLCD and KD on anthropometric indices, metabolic status, and hormonal levels in overweight or obese women with PCOS.</p><p><strong>Methods: </strong>This open-label, randomized clinical trial was conducted on forty-six PCOS women. 21 women in PMCD and 19 in the KD group completed the study. The anthropometric indices including body mass index (BMI) and fat body mass (FBM), metabolic markers (fasting blood glucose (FBG)) and plasma lipid profiles including low-density lipoprotein (LDL), triglycerides, and high-density lipoproteins (HDL) were measured. Reproductive hormones such as luteinizing hormone (LH), dehydroepiandrosterone sulfate (DHEA-s) and free testosterone were assessed at the baseline and after the intervention.</p><p><strong>Results: </strong>However, after 8 weeks both diets demonstrated enhancement in anthropometric indices (BMI, FBM, lean body mass), metabolic status (FBG, insulin serum levels), and reproductive hormones such as LH, free testosterone, and DHEA-s. The mean difference in the KD improved more than the PMCD in the field of BMI reduction (MD (SD) 2.73 (0.351) vs. MD (SD) 1.71 (0.775)) and LH (MD 4.13 (1.375) vs.MD 2.46 (1.105)). Nevertheless, the lipid profile including LDL-C and triglycerides improved more in the PMCD compared to the KD (MD 33.95 (7.345) vs. MD 23.34 (14.136)) and (MD 38.20 (10.757) vs. MD 57.62 (21.688)) respectively. There were no significant changes in the Ferriman-Gallwey score within or between the two groups.</p><p><strong>Conclusion: </strong>The findings revealed that both diets were effective in improving PCOS manifestations. However, the KD exhibited greater effectiveness in enhancing body measurements, metabolic factors, and reproductive hormone levels compared to the PMCD in obese PCOS women. Furthermore, PMCD could be more beneficial for PCOS women with lipide disorders.</p><p><strong>Registration number of clinical trial: </strong>IRCT20200912048693N3, Trial registered 2022-12-14. https://www.irct.ir/trial/67548.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"23 1","pages":"152"},"PeriodicalIF":4.4000,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11610292/pdf/","citationCount":"0","resultStr":"{\"title\":\"The effects of portfolio moderate-carbohydrate and ketogenic diets on anthropometric indices, metabolic status, and hormonal levels in overweight or obese women with polycystic ovary syndrome: a randomized controlled trial.\",\"authors\":\"Maryam Sharifi, Amir Saber, Jalal Moludi, Yahya Salimi, Alireza Jahan-Mihan\",\"doi\":\"10.1186/s12937-024-01056-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Polycystic Ovary Syndrome (PCOS) is one of the most common hormonal disorders in reproductive-age women caused by hyperinsulinemia. 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引用次数: 0
摘要
背景：多囊卵巢综合征（PCOS）是由高胰岛素血症引起的育龄妇女最常见的激素失调之一。组合适度碳水化合物饮食（PMCD）是一种以植物为基础的饮食，碳水化合物含量为40%，并包含五种降低胆固醇的食物。而生酮饮食是一种含有70%脂肪的高脂肪饮食，促进酮症状态。据我们所知，没有研究比较这两种饮食对多囊卵巢综合征患者的治疗效果。因此，本研究旨在比较PLCD和KD对超重或肥胖多囊卵巢综合征女性人体测量指标、代谢状况和激素水平的影响。方法：对46例PCOS妇女进行开放标签随机临床试验。21名患有PMCD的女性和19名患有KD的女性完成了研究。测量人体测量指标，包括体重指数（BMI）和脂肪体重（FBM）、代谢指标（空腹血糖（FBG））和血浆脂质谱，包括低密度脂蛋白（LDL）、甘油三酯和高密度脂蛋白（HDL）。在基线和干预后评估黄体生成素（LH）、硫酸脱氢表雄酮（DHEA-s）和游离睾酮等生殖激素。结果：然而，8周后，两种饮食都显示出人体测量指数（BMI， FBM，瘦体重），代谢状态（FBG，胰岛素血清水平）和生殖激素（LH，游离睾酮和DHEA-s）的增强。在BMI降低方面，KD的平均差异优于PMCD (MD (SD) 2.73 (0.351) vs MD （SD) 1.71(0.775)）和LH (MD (MD) 4.13 （1.375) vs MD 2.46(1.105)）。然而，与KD相比，PMCD患者的脂质谱（包括LDL-C和甘油三酯）改善更多(MD 33.95 （7.345) vs. MD 23.34(14.136)）和(MD 38.20 （10.757) vs. MD 57.62(21.688)）。Ferriman-Gallwey评分在两组内或两组之间没有显著变化。结论：两种饮食均能有效改善PCOS的表现。然而，与PMCD相比，KD在提高肥胖PCOS女性的身体测量、代谢因子和生殖激素水平方面表现出更大的有效性。此外，PMCD可能对患有脂质障碍的PCOS女性更有益。临床试验注册号：IRCT20200912048693N3，试验注册号为2022-12-14。https://www.irct.ir/trial/67548。
The effects of portfolio moderate-carbohydrate and ketogenic diets on anthropometric indices, metabolic status, and hormonal levels in overweight or obese women with polycystic ovary syndrome: a randomized controlled trial.
Background: Polycystic Ovary Syndrome (PCOS) is one of the most common hormonal disorders in reproductive-age women caused by hyperinsulinemia. The portfolio Moderate-carbohydrate diet (PMCD) is a plant-based diet with a carbohydrate content of 40% and incorporates five cholesterol-lowering foods. While, the ketogenic diet is a high-fat diet with 70% fat, promoting a ketosis state. To the best of our knowledge, no study compared the therapeutic effects of these two diets in PCOS patients. Thus, this study aimed to compare the impact of PLCD and KD on anthropometric indices, metabolic status, and hormonal levels in overweight or obese women with PCOS.
Methods: This open-label, randomized clinical trial was conducted on forty-six PCOS women. 21 women in PMCD and 19 in the KD group completed the study. The anthropometric indices including body mass index (BMI) and fat body mass (FBM), metabolic markers (fasting blood glucose (FBG)) and plasma lipid profiles including low-density lipoprotein (LDL), triglycerides, and high-density lipoproteins (HDL) were measured. Reproductive hormones such as luteinizing hormone (LH), dehydroepiandrosterone sulfate (DHEA-s) and free testosterone were assessed at the baseline and after the intervention.
Results: However, after 8 weeks both diets demonstrated enhancement in anthropometric indices (BMI, FBM, lean body mass), metabolic status (FBG, insulin serum levels), and reproductive hormones such as LH, free testosterone, and DHEA-s. The mean difference in the KD improved more than the PMCD in the field of BMI reduction (MD (SD) 2.73 (0.351) vs. MD (SD) 1.71 (0.775)) and LH (MD 4.13 (1.375) vs.MD 2.46 (1.105)). Nevertheless, the lipid profile including LDL-C and triglycerides improved more in the PMCD compared to the KD (MD 33.95 (7.345) vs. MD 23.34 (14.136)) and (MD 38.20 (10.757) vs. MD 57.62 (21.688)) respectively. There were no significant changes in the Ferriman-Gallwey score within or between the two groups.
Conclusion: The findings revealed that both diets were effective in improving PCOS manifestations. However, the KD exhibited greater effectiveness in enhancing body measurements, metabolic factors, and reproductive hormone levels compared to the PMCD in obese PCOS women. Furthermore, PMCD could be more beneficial for PCOS women with lipide disorders.
Registration number of clinical trial: IRCT20200912048693N3, Trial registered 2022-12-14. https://www.irct.ir/trial/67548.
期刊介绍：
Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered.
Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies.
In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.
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