线粒体综合应激反应：一种抗衰老和长寿的新方法。

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2024-11-26 DOI:10.1016/j.arr.2024.102603

Xiaoding Wang, Guangyu Zhang

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引用次数: 0

摘要

ISR是响应各种生理变化和刺激类型的细胞信号通路。线粒体综合应激反应（mitochondrial integrated stress response, ISRmt）是线粒体特异性的应激反应，由eIF2α磷酸化引发，对线粒体应激源有反应。ISRmt通过激活转录因子4 （ATF4）触发多种代谢反应。ISRmt的初始阶段可以引发适应性应激反应，对抗与年龄相关的疾病并促进长寿。在这篇综述中，我们概述了ISRmt的分子机制，特别关注其作为年龄相关疾病和促进长寿的治疗靶点的潜力。

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The mitochondrial integrated stress response: A novel approach to anti-aging and pro-longevity

The ISR is a cellular signaling pathway that responds to various physiological changes and types of stimulation. The mitochondrial integrated stress response (ISR^mt) is a stress response specific to mitochondria which is initiated by eIF2α phosphorylation and is responsive to mitochondrial stressors. The ISR^mt triggers diverse metabolic responses reliant on activating transcription factor 4 (ATF4). The preliminary phases of ISR^mt can provoke an adaptive stress response that antagonizes age-related diseases and promotes longevity. In this review, we provide an overview of the molecular mechanisms of the ISR^mt, with a particular focus on its potential as a therapeutic target for age-related disease and the promotion of longevity.

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.