1990 年至 2021 年全球、地区和国家脊髓损伤负担及 2050 年预测：2021 年全球疾病负担研究的系统分析。

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2024-11-26 DOI:10.1016/j.arr.2024.102598

Yubao Lu , Zhizhong Shang , Wei Zhang , Xuchang Hu , Ruoqi Shen , Keni Zhang , Yuxin Zhang , Liangming Zhang , Bin Liu , Mao Pang , Limin Rong

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引用次数: 0

摘要

目标：脊髓损伤（SCI）会导致严重的功能障碍和死亡，然而过时的流行病学数据却阻碍了有效的公共卫生政策的制定。本研究利用《2021 年全球疾病负担研究》（GBD 2021）的最新数据分析脊髓损伤的趋势，并为预防策略提供依据：方法：利用《2021 年全球疾病负担研究》（GBD 2021）的数据，我们研究了 SCI 的年龄标准化发病率、流行率和残疾生存年数（YLDs），以及趋势、驱动因素、年龄-性别-时间模式和直至 2050 年的预测：结果：2021 年，SCI 的负担（包括发病率、流行率和残疾生活年数）随着年龄的增长而增加。然而，发病率和YLDs在70岁达到峰值后略有下降，男性和女性的趋势相似。从 1990 年到 2021 年，包括男性和女性在内的所有人群的 SCI 全球负担均呈逐渐下降趋势，预计到 2050 年将进一步下降。然而，不同国家和地区之间的疾病负担存在显著差异；SDI 高的地区在达到峰值后逐渐下降，而 SDI 低的地区则从低水平逐渐上升。这种变化的主要驱动因素包括人口增长和老龄化，尽管流行病学的变化在一定程度上减轻了 SCI 的负担。研究还表明，男性和老年人，尤其是 70 岁及以上的老年人，承受着最严重的 SCI 负担，跌倒、道路伤害和人际暴力是造成这种状况的主要原因：尽管全球 SCI 的负担正在减轻，但不同人口和地区的复杂分布情况要求采取有针对性的预防和治疗策略，以进一步减轻负担并改善患者的预后。

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Global, regional, and national burden of spinal cord injury from 1990 to 2021 and projections for 2050: A systematic analysis for the Global Burden of Disease 2021 study

Objectives

Spinal cord injury (SCI) leads to significant functional impairments and mortality, yet outdated epidemiological data hinder effective public health policies. This study utilizes the latest data from the Global Burden of Disease Study 2021 (GBD 2021) to analyze SCI trends and inform prevention strategies.

Methods

Using GBD 2021 data, we examined age-standardized incidence, prevalence, and years lived with disability (YLDs) of SCI, along with trends, driving factors, age-sex-time patterns, and projections up to 2050.

Results

In 2021, the burden of SCI, including incidence, prevalence, and YLDs, increased with age. However, both prevalence and YLDs exhibited a slight decline after peaking at age 70, with similar trends observed in both males and females. From 1990–2021, the global burden of SCI showed a gradual decline across all populations, including males and females, and it is projected to decrease further by 2050. Nevertheless, significant disparities in disease burden exist between different countries and regions; high-SDI areas experienced a gradual decline after reaching a peak, while low-SDI areas saw a gradual increase from low levels. The primary drivers of this change include population growth and aging, although epidemiological shifts have somewhat alleviated the burden of SCI. The research also indicates that males and older adults, particularly those aged 70 and above, bear the most severe burden of SCI, with falls, road injuries, and interpersonal violence being the leading causes of this condition.

Conclusions

While the global burden of SCI is decreasing, the complex distribution across demographics and regions necessitates targeted prevention and treatment strategies to further reduce the burden and improve patient outcomes.

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.