以 TYK2 为靶标瞄准 tau

IF 28.7 1区医学 Q1 NEUROSCIENCES

Nature Reviews Neuroscience Pub Date : 2024-11-28 DOI:10.1038/s41583-024-00890-2

Caroline Barranco

引用次数: 0

摘要

在人类细胞系和转基因小鼠模型中进行的研究表明，非受体酪氨酸蛋白激酶 TYK2 可使 tau 在 Tyr29 处磷酸化，从而促进其稳定和积累。在小鼠中，敲除 TYK2 可降低 tau 水平并减轻 tau 神经病理学。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Targeting TYK2 to target tau

Studies in human cell lines and transgenic mouse models show that non-receptor tyrosine-protein kinase TYK2 phosphorylates tau at Tyr29 and thereby promotes its stabilization and accumulation. In mice, knockdown of TYK2 reduced tau levels and attenuated tau neuropathology.

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来源期刊

Nature Reviews Neuroscience NEUROSCIENCES-

自引率

0.60%

发文量

104

期刊介绍： Nature Reviews Neuroscience is a multidisciplinary journal that covers various fields within neuroscience, aiming to offer a comprehensive understanding of the structure and function of the central nervous system. Advances in molecular, developmental, and cognitive neuroscience, facilitated by powerful experimental techniques and theoretical approaches, have made enduring neurobiological questions more accessible. Nature Reviews Neuroscience serves as a reliable and accessible resource, addressing the breadth and depth of modern neuroscience. It acts as an authoritative and engaging reference for scientists interested in all aspects of neuroscience.