刺五加多糖通过调节 2 型糖尿病大鼠肝脏巨噬细胞的极化来改善炎症反应

IF 4.5 2区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Molecular Nutrition & Food Research Pub Date : 2024-11-26 DOI:10.1002/mnfr.202400392

Pei Zou, Xueyan Li, Liping Wang, Ying She, Chenyang Xiao, Yang Peng, Xu Qian, Peng Luo, Shaofeng Wei

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引用次数: 0

摘要

灰树花多糖（GFP）对 2 型糖尿病（T2DM）具有积极的调节作用，但人们对其调节机制的了解仍然有限。越来越多的证据表明，肝脏炎症对胰岛素抵抗（IR）和 T2DM 的发生和发展至关重要。然而，GFP 是否能通过调节肝脏炎症来调节 T2DM 及其机制尚未见报道。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Grifola frondosa Polysaccharide Ameliorates Inflammation by Regulating Macrophage Polarization of Liver in Type 2 Diabetes Mellitus Rats

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Grifola frondosa Polysaccharide Ameliorates Inflammation by Regulating Macrophage Polarization of Liver in Type 2 Diabetes Mellitus Rats

Grifola frondosa polysaccharide (GFP) has a positive effect in regulating type 2 diabetes mellitus (T2DM), but the understanding of its regulatory mechanism is still limited. Accumulating evidence suggests that hepatic inflammation is crucial in the onset and progression of insulin resistance (IR) and T2DM. However, the question of whether GFP can modulate T2DM via regulating hepatic inflammation and the underlying mechanism has not yet been reported.

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来源期刊

Molecular Nutrition & Food Research 工程技术-食品科技

CiteScore

8.70

自引率

1.90%

发文量

250

审稿时长

1.7 months

期刊介绍： Molecular Nutrition & Food Research is a primary research journal devoted to health, safety and all aspects of molecular nutrition such as nutritional biochemistry, nutrigenomics and metabolomics aiming to link the information arising from related disciplines: Bioactivity: Nutritional and medical effects of food constituents including bioavailability and kinetics. Immunology: Understanding the interactions of food and the immune system. Microbiology: Food spoilage, food pathogens, chemical and physical approaches of fermented foods and novel microbial processes. Chemistry: Isolation and analysis of bioactive food ingredients while considering environmental aspects.