{"title":"将铁突变与胸腺萎缩联系起来","authors":"Shirley Genah, Enrico Velardi","doi":"10.1038/s43587-024-00777-y","DOIUrl":null,"url":null,"abstract":"Age-related thymic involution compromises immune function, which leaves older adults more vulnerable to infections and to a potentially increased risk of cancer and autoimmune conditions. Jing, Song and colleagues identify the RNA methyltransferase METTL3, whose expression falters with age, as a key player in protecting developing thymocytes from ferroptosis.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"4 12","pages":"1673-1675"},"PeriodicalIF":17.0000,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Linking ferroptosis to thymic involution\",\"authors\":\"Shirley Genah, Enrico Velardi\",\"doi\":\"10.1038/s43587-024-00777-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Age-related thymic involution compromises immune function, which leaves older adults more vulnerable to infections and to a potentially increased risk of cancer and autoimmune conditions. Jing, Song and colleagues identify the RNA methyltransferase METTL3, whose expression falters with age, as a key player in protecting developing thymocytes from ferroptosis.\",\"PeriodicalId\":94150,\"journal\":{\"name\":\"Nature aging\",\"volume\":\"4 12\",\"pages\":\"1673-1675\"},\"PeriodicalIF\":17.0000,\"publicationDate\":\"2024-11-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature aging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s43587-024-00777-y\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature aging","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s43587-024-00777-y","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Age-related thymic involution compromises immune function, which leaves older adults more vulnerable to infections and to a potentially increased risk of cancer and autoimmune conditions. Jing, Song and colleagues identify the RNA methyltransferase METTL3, whose expression falters with age, as a key player in protecting developing thymocytes from ferroptosis.
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