{"title":"提高慢性阻塞性肺病患者的 NAD+ 可减轻气道炎症。","authors":"","doi":"10.1038/s43587-024-00765-2","DOIUrl":null,"url":null,"abstract":"Loss of nicotinamide adenine dinucleotide (NAD+) with aging may contribute to chronic obstructive pulmonary disease (COPD). In a randomized controlled trial, we show that six weeks of boosting NAD+ levels in patients with COPD reduces airway inflammation and might affect biological aging, possibly through a reduction in cellular senescence.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"4 12","pages":"1676-1677"},"PeriodicalIF":17.0000,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Boosting NAD+ in patients with COPD reduces airway inflammation\",\"authors\":\"\",\"doi\":\"10.1038/s43587-024-00765-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Loss of nicotinamide adenine dinucleotide (NAD+) with aging may contribute to chronic obstructive pulmonary disease (COPD). In a randomized controlled trial, we show that six weeks of boosting NAD+ levels in patients with COPD reduces airway inflammation and might affect biological aging, possibly through a reduction in cellular senescence.\",\"PeriodicalId\":94150,\"journal\":{\"name\":\"Nature aging\",\"volume\":\"4 12\",\"pages\":\"1676-1677\"},\"PeriodicalIF\":17.0000,\"publicationDate\":\"2024-11-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature aging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s43587-024-00765-2\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature aging","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s43587-024-00765-2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Boosting NAD+ in patients with COPD reduces airway inflammation
Loss of nicotinamide adenine dinucleotide (NAD+) with aging may contribute to chronic obstructive pulmonary disease (COPD). In a randomized controlled trial, we show that six weeks of boosting NAD+ levels in patients with COPD reduces airway inflammation and might affect biological aging, possibly through a reduction in cellular senescence.
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