Matthew J Valente, Jinyong Pang, Judith J M Rijnhart, John Ferron, Milica Miočević
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Estimating Mediation Effects in ABAB Reversal Designs.
Single-Case Experimental Designs (SCEDs), or N-of-1 trials, are commonly used to estimate intervention effects in many disciplines including in the treatment of youth mental health problems. SCEDs consist of repeated measurements of an outcome over time for a single case (e.g., student or patient) throughout one or more baseline phases and throughout one or more intervention phases. The manipulation of the baseline and intervention phase make the SCED a type of interrupted time series design, which is considered one of the most effective experimental designs for causal inference. An important step towards understanding why interventions are effective at producing a change in the outcome is through the investigation of mediating mechanisms. Hypotheses of mediating mechanisms involve an intervention variable which is hypothesized to affect an outcome through its effect on a mediating variable. Little work has attempted to combine mediation analysis and ABAB reversal designs. Therefore, the goals of this paper are to define, estimate, and interpret mediation effects for ABAB reversal designs. An empirical example is used to demonstrate how to estimate and interpret the mediation effects. R code is provided for researchers interested in estimating mediation effects in single-case reversal designs.
期刊介绍:
Evaluation & the Health Professions is a peer-reviewed, quarterly journal that provides health-related professionals with state-of-the-art methodological, measurement, and statistical tools for conceptualizing the etiology of health promotion and problems, and developing, implementing, and evaluating health programs, teaching and training services, and products that pertain to a myriad of health dimensions. This journal is a member of the Committee on Publication Ethics (COPE). Average time from submission to first decision: 31 days