{"title":"血清维生素 D 水平与血浆致动脉粥样硬化指数之间的关系：基于 2011-2018 年 NHANES 数据库的研究。","authors":"Tingting Hu, Ying Zhang, Zhu Chen, Jun Su","doi":"10.3389/fnut.2024.1468284","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This study aims to investigate the relationship between serum vitamin D levels and the atherogenic index of plasma (AIP) in individuals aged 20 years and above, as well as analyze potential influencing factors.</p><p><strong>Methods: </strong>A total of 9,637 participants aged 20 years and above from the National Health and Nutrition Examination Survey (NHANES) conducted between 2011 and 2018 were included in this study. The AIP was calculated using the formula log[triglycerides (TG)/high-density lipoprotein cholesterol (HDL-C)]. Due to the skewed distribution of serum vitamin D levels in the study population, a normal transformation was performed. Weighted multivariate linear regression models were used to assess the linear relationship between the transformed serum vitamin D levels and AIP. Subgroup analysis was conducted by stratifying the data based on age, gender, and race to evaluate the stability of the relationship between serum vitamin D levels and AIP in different populations. In addition, a smooth curve fitting and generalized linear models were employed to examine the nonlinear relationship between serum vitamin D levels and AIP.</p><p><strong>Results: </strong>After controlling for confounding factors, the multivariate linear regression analysis revealed a negative correlation between serum vitamin D levels and AIP [<i>β</i> = -0.0065, 95% CI: (-0.0106, -0.0024)]. This negative correlation was significant in male participants [<i>β</i> = -0.0077, 95% CI: (-0.0142, -0.0011)], Non-Hispanic Black participants [<i>β</i> = -0.0135, 95% CI: (-0.0211, -0.0059)], as well as participants aged 40-50 [<i>β</i> = -0.0124, 95% CI: (-0.0226, -0.0022)] and 60-70 [β = -0.0118, 95% CI: (-0.0214, -0.0023)]. Furthermore, a nonlinear relationship and saturation effect were observed between the transformed serum vitamin D levels and AIP, with a turning point at 8.5617 nmol/L.</p><p><strong>Conclusion: </strong>Our study revealed a significant negative correlation and saturation effect between serum vitamin D levels and AIP.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"11 ","pages":"1468284"},"PeriodicalIF":4.0000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11566743/pdf/","citationCount":"0","resultStr":"{\"title\":\"Relationship between serum vitamin D levels and the atherogenic index of plasma: a study based on NHANES database 2011-2018.\",\"authors\":\"Tingting Hu, Ying Zhang, Zhu Chen, Jun Su\",\"doi\":\"10.3389/fnut.2024.1468284\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This study aims to investigate the relationship between serum vitamin D levels and the atherogenic index of plasma (AIP) in individuals aged 20 years and above, as well as analyze potential influencing factors.</p><p><strong>Methods: </strong>A total of 9,637 participants aged 20 years and above from the National Health and Nutrition Examination Survey (NHANES) conducted between 2011 and 2018 were included in this study. The AIP was calculated using the formula log[triglycerides (TG)/high-density lipoprotein cholesterol (HDL-C)]. Due to the skewed distribution of serum vitamin D levels in the study population, a normal transformation was performed. Weighted multivariate linear regression models were used to assess the linear relationship between the transformed serum vitamin D levels and AIP. Subgroup analysis was conducted by stratifying the data based on age, gender, and race to evaluate the stability of the relationship between serum vitamin D levels and AIP in different populations. In addition, a smooth curve fitting and generalized linear models were employed to examine the nonlinear relationship between serum vitamin D levels and AIP.</p><p><strong>Results: </strong>After controlling for confounding factors, the multivariate linear regression analysis revealed a negative correlation between serum vitamin D levels and AIP [<i>β</i> = -0.0065, 95% CI: (-0.0106, -0.0024)]. This negative correlation was significant in male participants [<i>β</i> = -0.0077, 95% CI: (-0.0142, -0.0011)], Non-Hispanic Black participants [<i>β</i> = -0.0135, 95% CI: (-0.0211, -0.0059)], as well as participants aged 40-50 [<i>β</i> = -0.0124, 95% CI: (-0.0226, -0.0022)] and 60-70 [β = -0.0118, 95% CI: (-0.0214, -0.0023)]. Furthermore, a nonlinear relationship and saturation effect were observed between the transformed serum vitamin D levels and AIP, with a turning point at 8.5617 nmol/L.</p><p><strong>Conclusion: </strong>Our study revealed a significant negative correlation and saturation effect between serum vitamin D levels and AIP.</p>\",\"PeriodicalId\":12473,\"journal\":{\"name\":\"Frontiers in Nutrition\",\"volume\":\"11 \",\"pages\":\"1468284\"},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11566743/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Nutrition\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.3389/fnut.2024.1468284\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Nutrition","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.3389/fnut.2024.1468284","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
引用次数: 0
摘要
研究目的本研究旨在探讨20岁及以上人群血清维生素D水平与血浆致动脉粥样硬化指数（AIP）之间的关系，并分析潜在的影响因素：本研究共纳入2011年至2018年期间进行的美国国家健康与营养调查（NHANES）中的9637名20岁及以上参与者。AIP的计算公式为对数[甘油三酯（TG）/高密度脂蛋白胆固醇（HDL-C）]。由于研究人群的血清维生素 D 水平呈偏态分布，因此进行了正态转换。加权多变量线性回归模型用于评估转化后的血清维生素 D 水平与 AIP 之间的线性关系。根据年龄、性别和种族对数据进行分组分析，以评估不同人群中血清维生素 D 水平与 AIP 之间关系的稳定性。此外，还采用了平滑曲线拟合和广义线性模型来研究血清维生素 D 水平与 AIP 之间的非线性关系：在控制了混杂因素后，多变量线性回归分析显示血清维生素 D 水平与 AIP 之间存在负相关[β = -0.0065，95% CI：(-0.0106, -0.0024)]。这种负相关在男性参与者[β = -0.0077，95% CI：（-0.0142，-0.0011）]、非西班牙裔黑人参与者[β = -0.0135，95% CI：（-0.0211，-0.0059）]以及 40-50 岁[β = -0.0124，95% CI：（-0.0226，-0.0022）]和 60-70 岁[β = -0.0118，95% CI：（-0.0214，-0.0023）]参与者中显著。此外，转化后的血清维生素 D 水平与 AIP 之间存在非线性关系和饱和效应，转折点为 8.5617 nmol/L：我们的研究表明，血清维生素 D 水平与 AIP 之间存在明显的负相关和饱和效应。
Relationship between serum vitamin D levels and the atherogenic index of plasma: a study based on NHANES database 2011-2018.
Objective: This study aims to investigate the relationship between serum vitamin D levels and the atherogenic index of plasma (AIP) in individuals aged 20 years and above, as well as analyze potential influencing factors.
Methods: A total of 9,637 participants aged 20 years and above from the National Health and Nutrition Examination Survey (NHANES) conducted between 2011 and 2018 were included in this study. The AIP was calculated using the formula log[triglycerides (TG)/high-density lipoprotein cholesterol (HDL-C)]. Due to the skewed distribution of serum vitamin D levels in the study population, a normal transformation was performed. Weighted multivariate linear regression models were used to assess the linear relationship between the transformed serum vitamin D levels and AIP. Subgroup analysis was conducted by stratifying the data based on age, gender, and race to evaluate the stability of the relationship between serum vitamin D levels and AIP in different populations. In addition, a smooth curve fitting and generalized linear models were employed to examine the nonlinear relationship between serum vitamin D levels and AIP.
Results: After controlling for confounding factors, the multivariate linear regression analysis revealed a negative correlation between serum vitamin D levels and AIP [β = -0.0065, 95% CI: (-0.0106, -0.0024)]. This negative correlation was significant in male participants [β = -0.0077, 95% CI: (-0.0142, -0.0011)], Non-Hispanic Black participants [β = -0.0135, 95% CI: (-0.0211, -0.0059)], as well as participants aged 40-50 [β = -0.0124, 95% CI: (-0.0226, -0.0022)] and 60-70 [β = -0.0118, 95% CI: (-0.0214, -0.0023)]. Furthermore, a nonlinear relationship and saturation effect were observed between the transformed serum vitamin D levels and AIP, with a turning point at 8.5617 nmol/L.
Conclusion: Our study revealed a significant negative correlation and saturation effect between serum vitamin D levels and AIP.
期刊介绍：
No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health.
Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.
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