鉴定作为小儿脓毒性休克潜在诊断生物标志物的凝血相关基因。

IF 1.7 4区医学 Q3 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS

Computer Methods in Biomechanics and Biomedical Engineering Pub Date : 2025-01-01 Epub Date: 2024-11-13 DOI:10.1080/10255842.2024.2427121

Hong Li, Lihua Zhang, Yan Luo, Hua Yang, Xiaofang Qian, Lingling Zhan, Yanping Liao

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引用次数: 0

摘要

本研究旨在确定与儿童脓毒性休克相关的重要凝血相关基因（CRGs），并探索该疾病可能的重要机制。研究利用 GEO 数据库和文献数据确定了五个具有诊断性能的中心基因，这些中心基因与免疫细胞有很强的相关性。构建了 ceRNA 网络，以探索潜在的致病机制。确定了十种候选小分子化合物。总之，中枢基因可能在脓毒性休克的免疫和疾病发展中发挥重要作用，为今后脓毒性休克患儿的诊断和机制评估提供了新的思路和策略。

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Identification of coagulation-related genes as potential diagnostic biomarkers for pediatric septic shock.

This study aimed to identify important clotting associated genes (CRGs) associated with septic shock in children and explore possible important mechanisms of the disease. Five hub genes with diagnostic performance were identified using GEO database and data from literature. These hub genes have strong correlation with immune cells. ceRNA network was constructed to explore potential pathogenic mechanisms. Ten candidate small molecule compounds were identified. In summary, the hub genes may play an important role in the immunity and disease development of septic shock, providing new ideas and strategies for future diagnosis and mechanism evaluation of children with septic shock.

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来源期刊

Computer Methods in Biomechanics and Biomedical Engineering 工程技术-工程：生物医学

CiteScore

4.10

自引率

6.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： The primary aims of Computer Methods in Biomechanics and Biomedical Engineering are to provide a means of communicating the advances being made in the areas of biomechanics and biomedical engineering and to stimulate interest in the continually emerging computer based technologies which are being applied in these multidisciplinary subjects. Computer Methods in Biomechanics and Biomedical Engineering will also provide a focus for the importance of integrating the disciplines of engineering with medical technology and clinical expertise. Such integration will have a major impact on health care in the future.