开发用于离子束疗法剂量测定和微剂量测定的紧凑型便携式金刚石检测系统。

IF 1.3 4区 工程技术 Q3 INSTRUMENTS & INSTRUMENTATION
C Verona, A Fabbri, A Fazzi, L Bianchi, V Conte, G Petringa, A Raso, G Verona Rinati
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引用次数: 0

摘要

在过去二十年里,离子束治疗技术取得了长足的进步。然而,剂量测定验证方法的发展却相对滞后。传统的剂量测定方法提供了吸收剂量的宏观视图,但无法解决对了解生物反应至关重要的微观随机效应。为了弥补这一缺陷,微剂量计被用来评估与辐射效应相关的物理量。这项工作报告了基于合成单晶金刚石的新型检测系统的设计和测试情况。该系统能够同时对临床离子束进行剂量测定和微剂量测定。该探测器包含两个活性元件,配置为金刚石肖特基二极管,两者都集成在单晶金刚石基底上。其中,一个非常小的元件(灵敏面积为 0.0078 平方毫米)用于评估微剂量测定指标,而另一个大元件(灵敏面积为 4.2 平方毫米)则用于测量水的吸收剂量。利用离子束诱导电荷(IBIC)技术,采用 1 MeV 质子微束对金刚石探测器进行了表征。金刚石探测器的 IBIC 图显示了两个不同的敏感区域,敏感度相当一致,完全包含在金属接触区域内。为剂量测定和微剂量测定信号设计并实施了专用的前端电子电路。这些电路以及集成的金刚石探测器被嵌入一个铝制防水外壳中,以最大限度地减少电子干扰。这种配置使其成为一种与水模型兼容的紧凑型便携式装置。对α粒子进行的实验室测试取得了可喜的成果,显示出稳定、可重复的响应和良好的信噪比。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Development of a compact and portable diamond-based detection system for dosimetry and microdosimetry in ion beam therapy.

Ion beam therapy techniques have advanced significantly in the past two decades. However, the development of dosimetric verification methods has lagged. Traditional dosimetry, which offers a macroscopic view of the absorbed dose, fails to address the micrometric-scale stochastic effects crucial for understanding biological responses. To bridge this gap, microdosimeters are used to assess physical quantities correlated with radiation effects. This work reports on the design and testing of a novel detection system based on synthetic single crystal diamond. The system is capable of simultaneously performing dosimetric and microdosimetric characterizations of clinical ion beams. The detector incorporates two active components configured as diamond Schottky diodes, both integrated on a single crystal diamond substrate. In particular, one very small element (sensitive area 0.0078 mm2) was designed to evaluate microdosimetric metrics, while the other large one (sensitive area 4.2 mm2) was designed to measure the absorbed dose to water. Diamond detectors were characterized using the ion beam induced charge (IBIC) technique, employing a 1 MeV protons microbeam. The IBIC map of the diamond detector shows two distinct sensitive areas with quite uniform sensitivity, well contained within the metallic contact regions. Dedicated front-end electronic circuits were designed and implemented for both the dosimetric and microdosimetric signals. These circuits, along with the integrated diamond detector, were embedded in an aluminum waterproof housing to minimize electronic interference. This configuration enables a compact, portable setup compatible with water phantoms. Laboratory tests with alpha particles yielded promising results, demonstrating stable and reproducible responses with a good signal-to-noise ratio.

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来源期刊
Review of Scientific Instruments
Review of Scientific Instruments 工程技术-物理:应用
CiteScore
3.00
自引率
12.50%
发文量
758
审稿时长
2.6 months
期刊介绍: Review of Scientific Instruments, is committed to the publication of advances in scientific instruments, apparatuses, and techniques. RSI seeks to meet the needs of engineers and scientists in physics, chemistry, and the life sciences.
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