{"title":"维生素 D 不足与儿童肥胖症发病率的关系：对血清钙水平、碱性磷酸酶活性和骨骼成熟的影响。","authors":"Yue Xu, Lingyun Song, Li Zhou","doi":"10.3389/fnut.2024.1466270","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Vitamin D deficiency has been identified as a potential risk factor for various adverse health outcomes. However, its specific role in metabolic regulation and skeletal development in school-aged children is not fully understood. This study aimed to explore the correlation between vitamin D deficiency and childhood obesity rates, and its impact on serum calcium, alkaline phosphatase, and bone age in children.</p><p><strong>Methods: </strong>The study analyzed clinical data from 159 school-aged children who underwent medical examinations. Participants were divided into the 25-hydroxyvitamin D<sub>3</sub> (25(OH)D<sub>3</sub>) deficiency group and the 25(OH)D<sub>3</sub> normal group based on their serum levels. We compared body mass index (BMI), total cholesterol (TC), triglycerides (TG), Ca, ALP, bone age, fasting blood glucose (FBG), and hemoglobin A1c (HbA1c) between the two groups. Logistic regression and Spearman correlation analyses were performed to further investigate relationships between 25(OH)D<sub>3</sub> levels and metabolic and bone-related markers.</p><p><strong>Results: </strong>This study showed that the 25(OH)D<sub>3</sub> deficiency cohort exhibited significantly higher BMI, TC, TG, and ALP levels, with lower Ca levels and delayed bone age compared to the normal group. Logistic regression analysis identified Ca, ALP, and bone age as significant predictors of 25(OH)D<sub>3</sub> deficiency. Subgroup analysis showed that in the 25(OH)D<sub>3</sub> deficient group, children with higher BMI had elevated TC, ALP levels, and delayed bone age, while Ca levels were lower. Correlation analysis confirmed the predictive value of these markers for 25(OH)D<sub>3</sub> deficiency.</p><p><strong>Conclusion: </strong>Our findings demonstrate that 25(OH)D<sub>3</sub> deficiency is strongly associated with obesity in school-aged children and may negatively affect normal skeletal development. Regular monitoring of 25(OH)D<sub>3</sub> levels in school-aged children is essential for ensuring proper growth and development, especially in those at risk for obesity.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"11 ","pages":"1466270"},"PeriodicalIF":4.0000,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11557461/pdf/","citationCount":"0","resultStr":"{\"title\":\"The association of vitamin D insufficiency with the prevalence of obesity in children: implications for serum calcium levels, alkaline phosphatase activity, and bone maturation.\",\"authors\":\"Yue Xu, Lingyun Song, Li Zhou\",\"doi\":\"10.3389/fnut.2024.1466270\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Vitamin D deficiency has been identified as a potential risk factor for various adverse health outcomes. However, its specific role in metabolic regulation and skeletal development in school-aged children is not fully understood. This study aimed to explore the correlation between vitamin D deficiency and childhood obesity rates, and its impact on serum calcium, alkaline phosphatase, and bone age in children.</p><p><strong>Methods: </strong>The study analyzed clinical data from 159 school-aged children who underwent medical examinations. Participants were divided into the 25-hydroxyvitamin D<sub>3</sub> (25(OH)D<sub>3</sub>) deficiency group and the 25(OH)D<sub>3</sub> normal group based on their serum levels. We compared body mass index (BMI), total cholesterol (TC), triglycerides (TG), Ca, ALP, bone age, fasting blood glucose (FBG), and hemoglobin A1c (HbA1c) between the two groups. Logistic regression and Spearman correlation analyses were performed to further investigate relationships between 25(OH)D<sub>3</sub> levels and metabolic and bone-related markers.</p><p><strong>Results: </strong>This study showed that the 25(OH)D<sub>3</sub> deficiency cohort exhibited significantly higher BMI, TC, TG, and ALP levels, with lower Ca levels and delayed bone age compared to the normal group. Logistic regression analysis identified Ca, ALP, and bone age as significant predictors of 25(OH)D<sub>3</sub> deficiency. Subgroup analysis showed that in the 25(OH)D<sub>3</sub> deficient group, children with higher BMI had elevated TC, ALP levels, and delayed bone age, while Ca levels were lower. Correlation analysis confirmed the predictive value of these markers for 25(OH)D<sub>3</sub> deficiency.</p><p><strong>Conclusion: </strong>Our findings demonstrate that 25(OH)D<sub>3</sub> deficiency is strongly associated with obesity in school-aged children and may negatively affect normal skeletal development. Regular monitoring of 25(OH)D<sub>3</sub> levels in school-aged children is essential for ensuring proper growth and development, especially in those at risk for obesity.</p>\",\"PeriodicalId\":12473,\"journal\":{\"name\":\"Frontiers in Nutrition\",\"volume\":\"11 \",\"pages\":\"1466270\"},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2024-10-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11557461/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Nutrition\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.3389/fnut.2024.1466270\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Nutrition","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.3389/fnut.2024.1466270","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
引用次数: 0
摘要
背景：维生素 D 缺乏已被确定为导致各种不良健康后果的潜在风险因素。然而，人们对维生素 D 在学龄儿童新陈代谢调节和骨骼发育中的具体作用尚不完全了解。本研究旨在探讨维生素 D 缺乏与儿童肥胖率之间的相关性及其对儿童血清钙、碱性磷酸酶和骨龄的影响：研究分析了 159 名接受体检的学龄儿童的临床数据。根据血清中 25-羟基维生素 D3（25(OH)D3）的水平，将参与者分为 25-羟基维生素 D3（25(OH)D3）缺乏组和 25(OH)D3 正常组。我们比较了两组之间的体重指数（BMI）、总胆固醇（TC）、甘油三酯（TG）、Ca、ALP、骨龄、空腹血糖（FBG）和血红蛋白 A1c（HbA1c）。为进一步研究 25（OH）D3 水平与代谢和骨相关指标之间的关系，研究人员进行了逻辑回归和斯皮尔曼相关分析：研究结果表明，与正常组相比，25（OH）D3 缺乏组的 BMI、TC、TG 和 ALP 水平明显升高，Ca 水平降低，骨龄推迟。逻辑回归分析发现，钙、ALP和骨龄是25（OH）D3缺乏症的重要预测因素。亚组分析显示，在25（OH）D3缺乏组中，体重指数（BMI）较高的儿童TC、ALP水平升高，骨龄延迟，而Ca水平较低。相关分析证实了这些指标对25（OH）D3缺乏症的预测价值：我们的研究结果表明，25（OH）D3 缺乏与学龄儿童肥胖密切相关，并可能对正常骨骼发育产生负面影响。定期监测学龄儿童的 25（OH）D3 水平对确保其正常生长发育至关重要，尤其是那些有肥胖风险的儿童。
The association of vitamin D insufficiency with the prevalence of obesity in children: implications for serum calcium levels, alkaline phosphatase activity, and bone maturation.
Background: Vitamin D deficiency has been identified as a potential risk factor for various adverse health outcomes. However, its specific role in metabolic regulation and skeletal development in school-aged children is not fully understood. This study aimed to explore the correlation between vitamin D deficiency and childhood obesity rates, and its impact on serum calcium, alkaline phosphatase, and bone age in children.
Methods: The study analyzed clinical data from 159 school-aged children who underwent medical examinations. Participants were divided into the 25-hydroxyvitamin D3 (25(OH)D3) deficiency group and the 25(OH)D3 normal group based on their serum levels. We compared body mass index (BMI), total cholesterol (TC), triglycerides (TG), Ca, ALP, bone age, fasting blood glucose (FBG), and hemoglobin A1c (HbA1c) between the two groups. Logistic regression and Spearman correlation analyses were performed to further investigate relationships between 25(OH)D3 levels and metabolic and bone-related markers.
Results: This study showed that the 25(OH)D3 deficiency cohort exhibited significantly higher BMI, TC, TG, and ALP levels, with lower Ca levels and delayed bone age compared to the normal group. Logistic regression analysis identified Ca, ALP, and bone age as significant predictors of 25(OH)D3 deficiency. Subgroup analysis showed that in the 25(OH)D3 deficient group, children with higher BMI had elevated TC, ALP levels, and delayed bone age, while Ca levels were lower. Correlation analysis confirmed the predictive value of these markers for 25(OH)D3 deficiency.
Conclusion: Our findings demonstrate that 25(OH)D3 deficiency is strongly associated with obesity in school-aged children and may negatively affect normal skeletal development. Regular monitoring of 25(OH)D3 levels in school-aged children is essential for ensuring proper growth and development, especially in those at risk for obesity.
期刊介绍：
No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health.
Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.
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