在 D-半乳糖诱导的衰老模型中，麦角硫因可通过改善线粒体损伤和减少神经炎症来改善认知功能。

IF 5.1 1区农林科学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Food & Function Pub Date : 2024-11-12 DOI:10.1039/d4fo02321h

Fangyang Chen, Botao Wang, Xin Sun, Yage Wang, Ruiyan Wang, Kaikai Li

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引用次数: 0

摘要

麦角硫因（EGT）是一种含硫氨基酸，具有很强的抗氧化活性。本研究采用 D-半乳糖诱导的小鼠衰老模型来研究麦角硫因的抗衰老作用。干预 EGT 能明显改善衰老小鼠的识别记忆。此外，它还能改善 D-半乳糖诱导的神经元数量减少，提高大脑中 cAMP 和 BDNF 的水平，增加衰老小鼠 PSD95 的密度和表达。同时，EGT 还能通过 Nrf2/HO-1 途径降低 MDA 含量并增强 T-SOD 活性，从而减轻氧化应激。此外，EGT 还能通过调节 AMPK/SIRT1/PGC-1α 途径缓解线粒体功能，从而减轻 D-半乳糖诱导的海马神经元损伤，改善小鼠的学习和记忆能力。这项研究为改善年龄引起的记忆损伤提供了一种潜在的饮食策略。

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Ergothioneine improves cognitive function by ameliorating mitochondrial damage and decreasing neuroinflammation in a D-galactose-induced aging model.

Ergothioneine (EGT) is a sulfur-containing amino acid with strong antioxidant activity. In this study, a D-galactose induced mouse aging model was used to investigate the anti-aging effects of EGT. EGT intervention could significantly improve the recognition memory of aging mice. Additionally, it improved the D-galactose induced decrease in the number of neurones, enhanced the levels of cAMP and BDNF in the brain, and increased the density and expression of PSD95 in aging mice. Meanwhile, EGT could attenuate oxidative stress by reducing the content of MDA and enhancing T-SOD activity via the Nrf2/HO-1 pathway. In addition, EGT could alleviate mitochondrial function by regulating the AMPK/SIRT1/PGC-1α pathway, which in turn attenuated D-galactose induced hippocampal neuronal injury and improved the learning and memory abilities in mice. This study provides a potential dietary strategy to improve age-induced memory impairment.

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来源期刊

Food & Function BIOCHEMISTRY & MOLECULAR BIOLOGY-FOOD SCIENCE & TECHNOLOGY

CiteScore

10.10

自引率

6.60%

发文量

957

审稿时长

1.8 months

期刊介绍： Food & Function provides a unique venue for physicists, chemists, biochemists, nutritionists and other food scientists to publish work at the interface of the chemistry, physics and biology of food. The journal focuses on food and the functions of food in relation to health.