有节律的肝脏驱动摄食行为

IF 44.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2024-11-07 DOI:10.1126/science.adt0743

Noelia Martinez-Sanchez, David Ray

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引用次数: 0

摘要

肝迷走神经介导昼夜节律紊乱对小鼠食物摄入量的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Rhythmic liver drives feeding behavior

Timing mechanisms have evolved across all kingdoms of life to anticipate daily changes in the light environment and to optimize opportunities for nutrition. In mammals, the central circadian clock in the hypothalamic suprachiasmatic nucleus synchronizes to external light. However, other cells, tissues, and organs in the body have their own circadian clocks. For example, the liver has a molecular clock that can be entrained by feeding-fasting cycles. Desynchrony between the lightentrained suprachiasmatic nucleus and the food-entrained liver carries adverse health consequences, including increased risk of cardiometabolic diseases or type 2 diabetes; yet, how these clocks become misaligned remains unknown. On page 673 of this issue, Woodie et al. (1) report a neural link from the liver to the brain that conveys the misalignment signal to drive changes in eating behavior, body weight maintenance, and energy metabolism. This reveals a potential therapeutic target to mitigate the metabolic impact of circadian disruption.

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来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

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