不对称二甲基乙二胺水平与神经血管疾病风险：系统回顾与元分析》。

IF 4.5 2区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Molecular Nutrition & Food Research Pub Date : 2024-11-07 DOI:10.1002/mnfr.202400329

Qinqin Dai, Mengmeng Zhang, Yuanli Guo, Yuan Gao, Qilan Tang, Jiawei Zhao, Aixia Wang, Yuming Xu, Kai Liu

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引用次数: 0

摘要

研究范围本研究旨在提供明确的证据，可靠地量化非对称二甲基精氨酸（ADMA）水平与神经血管疾病风险之间的关系：对 Pubmed、Web of Science 和 Embase 进行了系统检索，以确定 2024 年 8 月之前发表的符合条件的研究。共确定了 31 项符合条件的研究。汇总结果表明，中风患者的 ADMA 水平高于健康对照组[标准化平均差 (SMD) = 1.02，95% CI = 0.92-1.12，P = 0.001]。亚组分析表明，地理位置、样本类型、事件数量和男性参与者比例是统计学上显著的异质性来源。同样，七项队列研究显示，ADMA 暴露与中风风险之间存在明显关联，汇总风险比 (RR) 为 1.60（95% CI = 1.60-1.91）。ADMA水平与小血管疾病（SVD）之间存在显著统计学差异（SMD = 0.33，95% CI = 0.07-0.58，p = 0.001）。此外，偏头痛患者的ADMA水平往往高于健康对照组（SMD = 0.39，95% CI = 0.11-0.67，P = 0.001）：我们的研究结果表明，ADMA水平对中风、SVD和偏头痛患者有显著影响。

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Levels of Asymmetric Dimethylar Ginine and Risk of Neurovascular Diseases: A Systematic Review and Meta-Analysis

Scope

The purpose of this study was to provide clear evidence that reliably quantifies the association of Asymmetric dimethylarginine (ADMA) levels with the risk of neurovascular diseases.

Methods and results

The Pubmed, Web of Science, and Embase were systematically searched to identify eligible studies published until August 2024. A total of 31 eligible studies were identified. Pooled results indicated that patients with stroke yielded a higher ADMA level than healthy controls [standardized mean difference (SMD) = 1.02, 95% CI = 0.92–1.12, P = 0.001]. Subgroup analyses showed that geographical location, sample type, number of events and the proportion of male participants were statistically significant sources of heterogeneity. Similarly, a significant association with a pooled risk ratio (RR) of 1.60 (95% CI = 1.60–1.91) was shown between ADMA exposure and the risk of stroke from seven cohort studies. There was a statistically significant difference between ADMA level and small vessel disease (SVD) (SMD = 0.33, 95% CI = 0.07–0.58, p = 0.001). In addition, migraine patients tend to have elevated ADMA levels compared to healthy controls (SMD = 0.39, 95% CI = 0.11–0.67, P = 0.001).

Conclusions

Our results indicate that ADMA levels have significant effects in patients with stroke, SVD, and migraine.

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来源期刊

Molecular Nutrition & Food Research 工程技术-食品科技

CiteScore

8.70

自引率

1.90%

发文量

250

审稿时长

1.7 months

期刊介绍： Molecular Nutrition & Food Research is a primary research journal devoted to health, safety and all aspects of molecular nutrition such as nutritional biochemistry, nutrigenomics and metabolomics aiming to link the information arising from related disciplines: Bioactivity: Nutritional and medical effects of food constituents including bioavailability and kinetics. Immunology: Understanding the interactions of food and the immune system. Microbiology: Food spoilage, food pathogens, chemical and physical approaches of fermented foods and novel microbial processes. Chemistry: Isolation and analysis of bioactive food ingredients while considering environmental aspects.