葡萄籽原花青素提取物(GSPE)能调节肝脏代谢基因和代谢产物的昼夜节律,并能减少食堂喂养大鼠的脂质沉积,且具有日时依赖性

IF 4.5 2区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY
Romina M. Rodríguez, Leonardo Vinícius Monteiro de Assis, Enrique Calvo, Marina Colom-Pellicer, Sergio Quesada-Vázquez, Álvaro Cruz-Carrión, Xavier Escoté, Henrik Oster, Gerard Aragonès, Miquel Mulero
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引用次数: 0

摘要

范围代谢功能障碍相关性脂肪性肝病(MASLD)是一个全球性的健康问题,发病率越来越高。多酚类物质,如葡萄籽原花青素提取物(GSPE),是植物中的生物活性化合物,是治疗代谢功能障碍相关性脂肪肝的一种有趣的方法。肝脏脂质分析和昼夜代谢基因表达及代谢组学研究结果显示,以食堂(CAF)饮食喂养的大鼠显示出葡萄糖稳态受损和肝脏脂肪生成增强,从而导致肝脏脂肪变性。在非活性或活性阶段长期食用 GSPE 会产生有益的影响,因为可以观察到转录物和代谢物的节律得到恢复。然而,只有在活性阶段服用 GSPE 才能降低肝脏甘油三酯水平。通过使用体外肝细胞模型,研究发现儿茶素(GSPE 提取物中的主要酚类化合物之一)是改善 CAF 诱导的肝脏脂肪变性的潜在介质。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Grape-Seed Proanthocyanidin Extract (GSPE) Modulates Diurnal Rhythms of Hepatic Metabolic Genes and Metabolites, and Reduces Lipid Deposition in Cafeteria-Fed Rats in a Time-of-Day-Dependent Manner

Grape-Seed Proanthocyanidin Extract (GSPE) Modulates Diurnal Rhythms of Hepatic Metabolic Genes and Metabolites, and Reduces Lipid Deposition in Cafeteria-Fed Rats in a Time-of-Day-Dependent Manner

Scope

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a global health issue with increasing prevalence. Polyphenols, such as grape seed proanthocyanidin extract (GSPE), are bioactive compounds present in plants and represent an interesting therapeutical approach for MASLD.

Methods and results

This study questioned whether the timing of GSPE administration impacts liver diurnal metabolism and steatosis in a rat obesity model. Results from hepatic lipid profiling and diurnal metabolic gene expression and metabolomics reveal that rats fed with a cafeteria (CAF) diet show impaired glucose homeostasis and enhanced lipogenesis in the liver, contributing to liver steatosis. Chronic consumption of GSPE in the inactive or active phase is associated with beneficial effects as the restoration of rhythms of transcripts and metabolites is observed. However, only when given in the active phase, GSPE treatment decreases hepatic triglyceride levels. Using an in vitro hepatocyte model, the study identifies that catechin, one of the main phenolic compounds found in the GSPE extract, is a potential mediator in ameliorating the effects of CAF-induced liver steatosis.

Conclusion

Taken altogether, the findings show that the beneficial effects of GSPE on MASLD development depend on the treatment time.

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来源期刊
Molecular Nutrition & Food Research
Molecular Nutrition & Food Research 工程技术-食品科技
CiteScore
8.70
自引率
1.90%
发文量
250
审稿时长
1.7 months
期刊介绍: Molecular Nutrition & Food Research is a primary research journal devoted to health, safety and all aspects of molecular nutrition such as nutritional biochemistry, nutrigenomics and metabolomics aiming to link the information arising from related disciplines: Bioactivity: Nutritional and medical effects of food constituents including bioavailability and kinetics. Immunology: Understanding the interactions of food and the immune system. Microbiology: Food spoilage, food pathogens, chemical and physical approaches of fermented foods and novel microbial processes. Chemistry: Isolation and analysis of bioactive food ingredients while considering environmental aspects.
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