一种典型蛋白复合物控制着免疫平衡和多种病原体的抵抗力

IF 44.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2024-11-07 DOI:10.1126/science.adr2138

Yue Wu, Weiying Xu, Guoyan Zhao, Ziyao Lei, Kui Li, Jiyun Liu, Shijia Huang, Junli Wang, Xiangbin Zhong, Xin Yin, Yuandong Wang, Haochen Zhang, Yang He, Zian Ye, Yonggang Meng, Xiaoyu Chang, Hui Lin, Xin Wang, Yuanyuan Gao, Jijie Chai, Jane E. Parker, Yiwen Deng, Yu Zhang, Mingjun Gao, Zuhua He

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引用次数: 0

摘要

Ca 2+ 传感器 ROD1 是水稻免疫的主调节器。通过筛选rod1突变体的抑制因子，我们发现ROD1通过监控典型免疫途径的激活来调节免疫稳态。OsTIR（TIR-only protein）、OsEDS1（Enhanced Disease Susceptibility 1）、OsPAD4（Phytoalexin Deficient 4）和OsADR1（Activated Disease Resistance 1）的突变都会削弱杆1植株的抗病性。OsTIR 催化产生第二信使 2′-（5′′-磷酸核糖基）-5′-腺苷单磷酸（pRib-AMP）和二磷酸（pRib-ADP），从而引发 OsEDS1-OsPAD4-OsADR1 （EPA）免疫复合物的形成。ROD1 与 OsTIR 相互作用并抑制其酶活性，而 ROD1 的突变会导致 EPA 复合物的持续激活。因此，我们揭示了一个免疫网络，它能微调水稻的免疫平衡和多病原抗性。

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A canonical protein complex controls immune homeostasis and multipathogen resistance

The Ca 2+ sensor, ROD1, is a master regulator of immunity in rice. By screening suppressors of rod1 mutants, we show that ROD1 governs immune homeostasis by surveilling the activation of a canonical immune pathway. Mutations in OsTIR ( TIR-only protein ), OsEDS1 ( Enhanced Disease Susceptibility 1 ), OsPAD4 ( Phytoalexin Deficient 4 ), and OsADR1 ( Activated Disease Resistance 1 ) all abolish enhanced disease resistance of rod1 plants. OsTIR catalyzes the production of second messengers 2′-(5′′-phosphoribosyl)-5′-adenosine monophosphate (pRib-AMP) and diphosphate (pRib-ADP), which trigger formation of an OsEDS1-OsPAD4-OsADR1 (EPA) immune complex. ROD1 interacts with OsTIR and inhibits its enzymatic activity while mutation of ROD1 leads to constitutive activation of the EPA complex. Thus, we unveil an immune network that fine-tunes immune homeostasis and multipathogen resistance in rice.

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来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

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