为期 6 个月的有氧运动干预对接受芳香化酶抑制剂治疗的乳腺癌女性患者大脑形态的影响:EPICC 试验的一项子研究。

IF 2.4 3区 医学 Q3 NEUROSCIENCES
Frontiers in Human Neuroscience Pub Date : 2024-10-23 eCollection Date: 2024-01-01 DOI:10.3389/fnhum.2024.1443916
Cristina Molina-Hidalgo, Lu Wan, Daniel Velazquez-Diaz, Haiqing Huang, George Grove, Catherine M Bender, Amanda L Gentry, Susan M Sereika, Chaeryon Kang, Mary E Crisafio, Kirk I Erickson
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引用次数: 0

摘要

目的:体育锻炼可增加成年后的脑容量和皮质厚度。然而,很少有研究探讨运动对接受乳腺癌治疗的女性大脑形态的影响。我们在一项随机临床试验中进行了一项嵌套子研究,以探讨对患有早期乳腺癌的绝经后妇女进行为期 6 个月的中等强度有氧运动是否会影响大脑形态:我们纳入了28名新确诊为0-IIIa期乳腺癌的绝经后妇女(中位年龄=62.96 ± 5.40),她们被随机分配参加每周3天、每次45-60分钟的有氧运动(16人)或常规护理(12人)。在开始芳香化酶抑制剂治疗和运动干预前,以及在6个月的随访中,从磁共振成像扫描中得出了体积和皮层厚度测量值:结果:干预对脑容量和皮质厚度没有明显影响。然而,干预期间平均运动强度(%)越大,干预后的皮质体积、平均皮质厚度、前中央回厚度和上顶叶厚度就越大(均 p < 0.05)。最后,总的监督锻炼时间与干预后更高的大脑前回厚度相关(p = 0.042,R 2 = 0.263):结论:与对照组相比,运动干预对脑容量和皮层厚度的影响并不明显。结论:与对照组相比,运动干预并未对脑体积和皮层厚度产生明显影响,但在为期6个月的干预后,发现运动强度与脑形态变化之间存在正相关,这表明运动可降低大脑对乳腺癌及其治疗的有害影响的脆弱性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of a 6-month aerobic exercise intervention on brain morphology in women with breast cancer receiving aromatase inhibitor therapy: a sub-study of the EPICC trial.

Objective: Physical exercise may increase brain volume and cortical thickness in late adulthood. However, few studies have examined the possibility for exercise to influence brain morphology in women treated for breast cancer. We conducted a nested sub-study within a randomized clinical trial to examine whether 6 months of moderate-intensity aerobic exercise in postmenopausal women with early-stage breast cancer influences brain morphology.

Methods: We included twenty-eight postmenopausal women newly diagnosed with Stage 0-IIIa breast cancer (M age = 62.96 ± 5.40) who were randomized to either 45-60 min of supervised aerobic exercise 3 days/week (n = 16) or usual care (n = 12). Before beginning aromatase inhibitor aromatase inhibitor therapy, and the exercise intervention, and again at 6-month follow-up, volumetric and cortical thickness measures were derived from magnetic resonance imaging scans.

Results: There were no significant intervention effects on brain volume and cortical thickness. However, greater average exercise intensity (%) during the intervention was associated with greater post-intervention cortical volume, mean cortical thickness, precentral gyrus thickness, and superior parietal thickness (all p < 0.05). Finally, total supervised exercise time was associated with higher precentral gyrus thickness after the intervention (p = 0.042, R 2 = 0.263).

Conclusion: The exercise intervention did not significantly affect brain volumes and cortical thickness compared to the control group. However, positive associations were found between exercise intensity and brain morphology changes after the 6-month intervention, indicating that exercise may reduce the vulnerability of the brain to the deleterious effects of breast cancer and its treatment.

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来源期刊
Frontiers in Human Neuroscience
Frontiers in Human Neuroscience 医学-神经科学
CiteScore
4.70
自引率
6.90%
发文量
830
审稿时长
2-4 weeks
期刊介绍: Frontiers in Human Neuroscience is a first-tier electronic journal devoted to understanding the brain mechanisms supporting cognitive and social behavior in humans, and how these mechanisms might be altered in disease states. The last 25 years have seen an explosive growth in both the methods and the theoretical constructs available to study the human brain. Advances in electrophysiological, neuroimaging, neuropsychological, psychophysical, neuropharmacological and computational approaches have provided key insights into the mechanisms of a broad range of human behaviors in both health and disease. Work in human neuroscience ranges from the cognitive domain, including areas such as memory, attention, language and perception to the social domain, with this last subject addressing topics, such as interpersonal interactions, social discourse and emotional regulation. How these processes unfold during development, mature in adulthood and often decline in aging, and how they are altered in a host of developmental, neurological and psychiatric disorders, has become increasingly amenable to human neuroscience research approaches. Work in human neuroscience has influenced many areas of inquiry ranging from social and cognitive psychology to economics, law and public policy. Accordingly, our journal will provide a forum for human research spanning all areas of human cognitive, social, developmental and translational neuroscience using any research approach.
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