多酚治疗中风:氧化应激调节的作用。

IF 5.1 1区 农林科学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Food & Function Pub Date : 2024-11-05 DOI:10.1039/d4fo01900h
Yusong Luo, Ruolan Liu, Guoqiang Yuan, Yawen Pan
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引用次数: 0

摘要

中风的发病率和致残率都很高,严重危害人类健康。氧化应激(Oxidative stress,OS)在脑卒中脑损伤的病理发展过程中起着至关重要的作用。新近的实验研究表明,多酚类物质具有抗氧化潜力,在不同类型的中风后具有保护作用,但在临床研究中尚未取得突破性进展。纳米材料因其尺寸小的特点,可用于递送药物,在治疗各种疾病方面表现出色。纳米材料的给药能力对多酚的临床转化和应用具有重要意义。本综述介绍了脑卒中氧化应激机制,总结了多酚类化合物对脑卒中后活性氧生成和氧化应激的抗氧化作用。此外,还介绍了纳米材料在中风抗氧化治疗中的应用特点和研究进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Polyphenols for stroke therapy: the role of oxidative stress regulation.

Stroke is associated with a high incidence and disability rate, which seriously endangers human health. Oxidative stress (OS) plays a crucial role in the underlying pathologic progression of cerebral damage in stroke. Emerging experimental studies suggest that polyphenols have antioxidant potential and express protective effects after different types of strokes, but no breakthrough has been achieved in clinical studies. Nanomaterials, due to small characteristic sizes, can be used to deliver drugs, and have shown excellent performance in the treatment of various diseases. The drug delivery capability of nanomaterials has significant implications for the clinical translation and application of polyphenols. This comprehensive review introduces the mechanism of oxidative stress in stroke, and also summarizes the antioxidant effects of polyphenols on reactive oxygen species generation and oxidative stress after stroke. Also, the application characteristics and research progress of nanomaterials in the treatment of stroke with antioxidants are presented.

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来源期刊
Food & Function
Food & Function BIOCHEMISTRY & MOLECULAR BIOLOGY-FOOD SCIENCE & TECHNOLOGY
CiteScore
10.10
自引率
6.60%
发文量
957
审稿时长
1.8 months
期刊介绍: Food & Function provides a unique venue for physicists, chemists, biochemists, nutritionists and other food scientists to publish work at the interface of the chemistry, physics and biology of food. The journal focuses on food and the functions of food in relation to health.
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