晚期多发性硬化症患者的视网膜功能。

IF 5 2区 医学 Q1 OPHTHALMOLOGY
James V M Hanson, Sara Single, Rahel B Eberle, Veronika Kana, Benjamin V Ineichen, Christina Gerth-Kahlert
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引用次数: 0

摘要

目的:多发性硬化症患者(pwMS)的整个中枢神经系统都会经历自身免疫介导的炎症和神经变性。目前仍需要临床上可获得的、可靠的多发性硬化症神经变性功能标志物。先前的研究描述了视网膜电图(ERG)衍生的视网膜双极细胞功能测量指标在多发性硬化症病程早期的变化。因此,我们将视网膜电图(ERG)作为疾病晚期患者的潜在结果测量指标进行了研究:这项横断面观察性研究纳入了残疾状况扩展量表(EDSS)评分≥3.0 的多发性硬化症患者和健康对照组(HC)患者,他们都接受了 ERG、光学相干断层扫描、高低对比度视力测量和眼科检查。将患有和未患有视神经炎(MS +ON;MS -ON)的 MS 患者的 ERG 结果与 HC 患者的 ERG 结果进行了比较。测量了 EDSS、病程、ON 和治疗状态对选定 ERG 结果的影响。其他探索性分析评估了MS表型和疾病状态(临床活动、放射学活动和疾病进展)的潜在影响:结果:在MS +ON和MS -ON眼中记录了两个ERG峰值时间(暗适应3.0 b波;光适应闪烁)的延迟。未观察到 EDSS 评分、病程、既往 ON 或治疗状态的影响。探索性分析结果表明,多发性硬化症表型或疾病状态没有影响:结论:多发性硬化症导致的中重度残疾患者的ERG结果异常,但这些结果与病程早期观察到的结果并无不同。虽然在整个病程中,双极功能障碍似乎在患者中很常见,但ERG可能对多发性硬化症的监测或预后没有帮助。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Retinal Function in Advanced Multiple Sclerosis.

Purpose: People with multiple sclerosis (pwMS) experience autoimmunity-mediated inflammation and neurodegeneration throughout the central nervous system. There remains a need for clinically accessible, reliable functional markers of neurodegeneration in MS. Previous research has described changes to electroretinography (ERG)-derived measures of retinal bipolar cell function in pwMS early in the disease course. We, therefore, investigated ERG as a potential outcome measure in individuals with more advanced disease.

Methods: This cross-sectional observational study included pwMS with Expanded Disability Status Scale (EDSS) scores of ≥3.0 and healthy control (HC) participants who underwent ERG, optical coherence tomography, high- and low-contrast visual acuity measurement, and an ophthalmological examination. ERG findings in MS eyes with and without previous optic neuritis (MS +ON; MS -ON) were compared with those in HC eyes. Effects of EDSS, disease duration, ON, and treatment status on selected ERG outcomes were measured. Additional exploratory analyses assessed potential influences of MS phenotype and disease status (clinically active, radiologically active, and disease progression).

Results: Delays to two ERG peak times (dark-adapted 3.0 b-wave; light-adapted flicker) were recorded in MS +ON and MS -ON eyes. No influences of EDSS score, disease duration, previous ON, or treatment status were observed. Exploratory analyses were consistent with no effects of MS phenotype or disease status.

Conclusions: ERG findings are abnormal in individuals with moderate-severe disability caused by MS; however, these findings are not distinct from those observed earlier in the disease course. Although bipolar dysfunction appears to be common in pwMS throughout the disease course, ERG is likely not useful in monitoring or prognostication of MS.

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来源期刊
CiteScore
6.90
自引率
4.50%
发文量
339
审稿时长
1 months
期刊介绍: Investigative Ophthalmology & Visual Science (IOVS), published as ready online, is a peer-reviewed academic journal of the Association for Research in Vision and Ophthalmology (ARVO). IOVS features original research, mostly pertaining to clinical and laboratory ophthalmology and vision research in general.
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