极低频电磁场（50 Hz）可以为大鼠脑室-去甲肾上腺素能（LC-NA）系统的活动建立一个新的 "设定点"。

IF 3.5 3区医学 Q2 NEUROSCIENCES

Brain Research Bulletin Pub Date : 2024-10-31 DOI:10.1016/j.brainresbull.2024.111111

Angelika Klimek , Hanna Kletkiewicz , Agnieszka Siejka , Joanna Wyszkowska , Justyna Maliszewska , Maciej Klimiuk , Milena Jankowska , Justyna Rogalska

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引用次数: 0

摘要

近几十年来，生物体暴露于极低频电磁场（ELF-EMF；50Hz）的情况与日俱增，这与蓬勃发展的技术有关。ELF-EMF被认为是一种应激因素，其对生物体的影响仍在研究之中。我们的目的是确定其对使大鼠适应应激条件的脑皮质-去甲肾上腺素能（LC-NA）系统的影响。为此，我们将大鼠暴露于 1 和 7 mT 的 50Hz ELF-EMF 中，每天 1 小时，持续 7 天。这一过程重复进行了三次，以检查机体的适应能力。随后，对肾上腺素、去甲肾上腺素及其代谢物 MHPG 的浓度以及 β2-肾上腺素能受体的表达进行了评估。每次暴露结束后，对部分动物进行行为测试，以评估重复暴露ELF-EMF对后续应激因素的应激反应的影响。我们的研究证明，ELF-EMF对应激反应的影响机制包括LC-NA系统。1 mT的ELF-EMF可引起NA-LC系统的适应性变化。然而，暴露于 7 mT 会导致应激系统的活动增加，从而对后续的异型（不同于先前作用的）应激因子产生敏感性。由于 7 mT 的 ELF-EMF 会导致β2-AR 水平显著下降，这将强烈抑制海马神经可塑性过程的潜力。此外，暴露于 7 mT ELF-EMF 的大鼠表现出中度增加的焦虑相关行为。NA-LC传递紊乱可能是某些神经退行性疾病和精神疾病的发病原因，这表明ELF-EMF可能与这些疾病的发病机制有关。

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The extremely low-frequency electromagnetic field (50 Hz) can establish a new “set-point” for the activity of the locus coeruleus–noradrenergic (LC-NA) system in rat

Exposure of organisms to extremely low-frequency electromagnetic field (ELF-EMF; 50 Hz) has been increasing in recent decades, which is connected with dynamic technological development. ELF-EMF is considered a stress factor and its effects on organisms are still being investigated. We aimed to determine its impact on the locus coeruleus–noradrenergic (LC-NA) system enabling adaptation to stressful conditions. For this purpose, we exposed rats to 50 Hz ELF-EMF of 1 and 7 mT, 1 h/day for 7 days. The procedure was repeated three times to examine the organism's adaptive capabilities. Subsequently, the concentration of adrenaline, noradrenaline and its metabolite MHPG as well as the expression of the β2-adrenergic receptor was assessed. After the end of each exposure, part of the animals were subjected to a behavioural test to assess the influence of repeated ELF-EMF exposure on stress response to subsequent stress factors. Our research proved that mechanisms underlying the effects of ELF-EMF on stress response include the LC-NA system. ELF-EMF of 1 mT induced adaptive changes in the NA-LC system. However, exposure to 7 mT caused increased activity of the stress system which resulted in sensitization to subsequent, heterotypic (different from the one previously acting) stress factor. As ELF-EMF of 7 mT caused a profound decrease in β2-AR level would strongly inhibit the potential for neuroplastic processes in the hippocampus. Moreover, rats exposed to ELF-EMF of 7 mT showed moderately increased anxiety-related behaviour. Disturbances in NA-LC transmission may underlie the development of some neurodegenerative and psychiatric diseases which indicates the possible involvement of ELF-EMF in the pathogenesis of these disorders.

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来源期刊

Brain Research Bulletin 医学-神经科学

CiteScore

6.90

自引率

2.60%

发文量

253

审稿时长

67 days

期刊介绍： The Brain Research Bulletin (BRB) aims to publish novel work that advances our knowledge of molecular and cellular mechanisms that underlie neural network properties associated with behavior, cognition and other brain functions during neurodevelopment and in the adult. Although clinical research is out of the Journal''s scope, the BRB also aims to publish translation research that provides insight into biological mechanisms and processes associated with neurodegeneration mechanisms, neurological diseases and neuropsychiatric disorders. The Journal is especially interested in research using novel methodologies, such as optogenetics, multielectrode array recordings and life imaging in wild-type and genetically-modified animal models, with the goal to advance our understanding of how neurons, glia and networks function in vivo.