细菌分裂征服抗生素

IF 44.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2024-10-31 DOI:10.1126/science.adt0042

Ewan Harrison

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引用次数: 0

摘要

对甲氧西林的高度抗药性需要一种独特的细胞分裂形式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Bacteria divide to conquer antibiotics

Antibiotics are a cornerstone of modern medicine, and consequently, antibiotic resistance is a serious public health threat to treating bacterial infections. Shortly after penicillin came into clinical use to treat Staphylococcus aureus—a pathogen that can cause mild to fatal infections—strains resistant to the drug emerged. In 1959, the antibiotic methicillin was introduced to treat penicillin-resistant strains of S. aureus. Methicillin is a member of the β-lactam family of antibiotics that are broadly effective against many types of bacteria. However, by 1960, infections with methicillin-resistant S. aureus (MRSA) had been reported (1). Given the importance of β-lactams for treating S. aureus infections, researchers have sought to understand the mechanism and evolutionary origins of this resistance. On page 573 of this issue, Adedeji-Olulana et al. (2) report that high-level resistance to methicillin requires S. aureus to use a distinct form of cell division to ensure its survival.

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来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

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