出生后最初 1000 天内接触糖配给可预防慢性疾病

IF 44.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2024-10-31 DOI:10.1126/science.adn5421

Tadeja Gracner, Claire Boone, Paul J. Gertler

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引用次数: 0

摘要

我们利用英国 1953 年 9 月结束食糖配给后的准实验数据，研究了受孕 1000 天内摄入糖分对糖尿病和高血压的影响。配给制将糖的摄入量限制在现行膳食指南规定的范围内，但配给制结束后，糖的消费量立即增加了近一倍。我们利用英国生物库数据进行了一项事件研究设计，比较了配给结束前或配给结束后受孕的成年人，发现早期配给分别降低了约 35% 和 20% 的糖尿病和高血压风险，并将发病时间分别推迟了 4 年和 2 年。这种保护作用在胎儿时期就很明显，并随着出生后的限糖而增加，尤其是在六个月后开始吃固体食物时。仅胎内糖分配给就降低了约三分之一的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Exposure to sugar rationing in the first 1000 days of life protected against chronic disease

We examined the impact of sugar exposure within 1000 days since conception on diabetes and hypertension, leveraging quasi-experimental variation from the end of the United Kingdom’s sugar rationing in September 1953. Rationing restricted sugar intake to levels within current dietary guidelines, yet consumption nearly doubled immediately post-rationing. Using an event study design with UK Biobank data comparing adults conceived just before or after rationing ended, we found that early-life rationing reduced diabetes and hypertension risk by about 35% and 20%, respectively, and delayed disease onset by 4 and 2 years. Protection was evident with in-utero exposure and increased with postnatal sugar restriction, especially after six months when solid foods likely began. In-utero sugar rationing alone accounted for about one third of the risk reduction.

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来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

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