银屑病的线场共焦光学相干断层成像与组织病理学相关性。

IF 1.6 4区 医学 Q3 DERMATOLOGY
Anna Elisa Verzì, Francesco Lacarrubba, Maria Letizia Musumeci, Rosario Caltabiano, Giuseppe Micali
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引用次数: 0

摘要

线场共焦光学相干断层扫描(LC-OCT)是一种用于活体皮肤检查的新型成像技术,最近被引入皮肤科的无创诊断工具中。它在一些肿瘤性、炎症性和感染性皮肤病的诊断和治疗监测中的作用已得到证实。本研究旨在评估大量银屑病斑块的 LC-OCT 特征及其组织病理学相关性。在这项回顾性研究中,对 60 名患者的 100 块躯干、上臂和下臂银屑病斑块的 LC-OCT 图像和相应的组织病理学图像进行了评估和关联。在 LC-OCT 和组织病理学检查中均观察到以下典型的斑块状银屑病显微镜检查结果:角化过度、角化不全、棘层增生、乳头状瘤病和血管病变、Munro 微脓肿和 Kogoj 脓疱。LC-OCT 的发现与组织病理学完全吻合。我们的研究证实了这种新型成像技术在无创观察银屑病常见诊断线索方面的实用性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Line-Field Confocal Optical Coherence Tomography Imaging of Psoriasis With Histopathology Correlation.

Line-field confocal optical coherence tomography (LC-OCT) is a novel imaging technique for in vivo examination of the skin that has recently been introduced in the dermatologic armamentarium of non-invasive diagnostic tools. Its usefulness in the diagnosis and treatment monitoring of some neoplastic, inflammatory, and infectious skin conditions has been demonstrated. The aim of this study was to evaluate the LC-OCT features of psoriasis in a large number of psoriatic plaques along with their histopathologic correlation. In this retrospective study, the LC-OCT and the corresponding histopathologic images of 100 psoriatic plaques of the trunk, upper and lower arms from 60 patients that underwent both procedures were evaluated and correlated. The following microscopic findings, typical of plaque psoriasis, were observed at both LC-OCT and histopathology: hyperkeratosis, parakeratosis, acanthosis, papillomatosis and vascular changes, Munro microabscesses, and pustules of Kogoj. The LC-OCT findings perfectly matched with histopathology. Our study confirms the usefulness of this new imaging technique in the non-invasive visualization of the common diagnostic clues of psoriasis.

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来源期刊
CiteScore
3.20
自引率
5.90%
发文量
174
审稿时长
3-8 weeks
期刊介绍: Journal of Cutaneous Pathology publishes manuscripts broadly relevant to diseases of the skin and mucosae, with the aims of advancing scientific knowledge regarding dermatopathology and enhancing the communication between clinical practitioners and research scientists. Original scientific manuscripts on diagnostic and experimental cutaneous pathology are especially desirable. Timely, pertinent review articles also will be given high priority. Manuscripts based on light, fluorescence, and electron microscopy, histochemistry, immunology, molecular biology, and genetics, as well as allied sciences, are all welcome, provided their principal focus is on cutaneous pathology. Publication time will be kept as short as possible, ensuring that articles will be quickly available to all interested in this speciality.
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