Juan-Camilo Vargas-Gonzalez, Antonella Santuccione Chadha, Laura Castro-Aldrete, Maria Teresa Ferretti, Maria Carmela Tartaglia
{"title":"信息提供者的特征会影响基于临床痴呆分级的阿尔茨海默病分期。","authors":"Juan-Camilo Vargas-Gonzalez, Antonella Santuccione Chadha, Laura Castro-Aldrete, Maria Teresa Ferretti, Maria Carmela Tartaglia","doi":"10.1038/s43587-024-00732-x","DOIUrl":null,"url":null,"abstract":"<p><p>The Clinical Dementia Rating Sum of Boxes (CDR-SB) is a staging scale for Alzheimer's disease (AD)<sup>1</sup> and is commonly used as an outcome in clinical trials<sup>2</sup>. It relies on information provided by the patient and an informant<sup>3</sup>. The CDR-SB should reflect only the patient's disease severity. However, we explored whether informant characteristics were associated with CDR-SB scores because that association might introduce bias in Alzheimer's disease research. We found that the CDR-SB was 0.20 higher when informants were female, 0.39 higher when the informant was a patient's child and 0.18 lower if the relationship was other than spouse or children. Regarding the frequency of contact, CDR-SB scores were 0.38 higher when contact was at least once a week, 0.65 higher when daily and 0.57 higher when living with the patient. Our analysis results suggest that informant characteristics can modify the CDR-SB scores and might introduce bias into Alzheimer's disease trials and research.</p>","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":null,"pages":null},"PeriodicalIF":17.0000,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Informant characteristics influence Clinical Dementia Rating Sum of Boxes scores-based staging of Alzheimer's disease.\",\"authors\":\"Juan-Camilo Vargas-Gonzalez, Antonella Santuccione Chadha, Laura Castro-Aldrete, Maria Teresa Ferretti, Maria Carmela Tartaglia\",\"doi\":\"10.1038/s43587-024-00732-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The Clinical Dementia Rating Sum of Boxes (CDR-SB) is a staging scale for Alzheimer's disease (AD)<sup>1</sup> and is commonly used as an outcome in clinical trials<sup>2</sup>. It relies on information provided by the patient and an informant<sup>3</sup>. The CDR-SB should reflect only the patient's disease severity. However, we explored whether informant characteristics were associated with CDR-SB scores because that association might introduce bias in Alzheimer's disease research. We found that the CDR-SB was 0.20 higher when informants were female, 0.39 higher when the informant was a patient's child and 0.18 lower if the relationship was other than spouse or children. Regarding the frequency of contact, CDR-SB scores were 0.38 higher when contact was at least once a week, 0.65 higher when daily and 0.57 higher when living with the patient. Our analysis results suggest that informant characteristics can modify the CDR-SB scores and might introduce bias into Alzheimer's disease trials and research.</p>\",\"PeriodicalId\":94150,\"journal\":{\"name\":\"Nature aging\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":17.0000,\"publicationDate\":\"2024-10-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature aging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1038/s43587-024-00732-x\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature aging","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s43587-024-00732-x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Informant characteristics influence Clinical Dementia Rating Sum of Boxes scores-based staging of Alzheimer's disease.
The Clinical Dementia Rating Sum of Boxes (CDR-SB) is a staging scale for Alzheimer's disease (AD)1 and is commonly used as an outcome in clinical trials2. It relies on information provided by the patient and an informant3. The CDR-SB should reflect only the patient's disease severity. However, we explored whether informant characteristics were associated with CDR-SB scores because that association might introduce bias in Alzheimer's disease research. We found that the CDR-SB was 0.20 higher when informants were female, 0.39 higher when the informant was a patient's child and 0.18 lower if the relationship was other than spouse or children. Regarding the frequency of contact, CDR-SB scores were 0.38 higher when contact was at least once a week, 0.65 higher when daily and 0.57 higher when living with the patient. Our analysis results suggest that informant characteristics can modify the CDR-SB scores and might introduce bias into Alzheimer's disease trials and research.