mGluR7：保护中枢神经系统的新角色。

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2024-10-24 DOI:10.1016/j.arr.2024.102554

Pan Li , Wangrui Lei , Yushu Dong , Xiaowu Wang , Xingyan Ye , Ye Tian , Yaru Yang , Jie Liu , Ning Li , Xiaochen Niu , Xin Wang , Yifan Tian , Lu Xu , Yang Yang , Jincheng Liu

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引用次数: 0

摘要

拟代谷氨酸受体7（mGluR7）属于III型mGluR受体家族，在中枢神经系统（CNS）中发挥着重要作用，包括对神经递质调节的反应、降低兴奋毒性和早期神经元发育。因此，以 mGluR7 为靶点的药物（mGluR7 激动剂、拮抗剂和异位调节剂）可能是治疗中枢神经系统疾病（如精神疾病、神经退行性疾病和神经发育障碍）的最有前景的药物之一，尽管这些潜在疗法还处于早期阶段，数据仍然有限。在这篇综述中，我们总结了 mGluR7 的结构和功能，并讨论了 mGluR7 激动剂和拮抗剂的最新研究进展。深入了解 mGluR7 将有助于揭示神经保护的分子机制，并为制定治疗策略提供理论依据。

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mGluR7: The new player protecting the central nervous system

Metabotropic glutamate receptor 7 (mGluR7) belongs to the family of type III mGluR receptor, playing an important part in the central nervous system (CNS) through response to neurotransmitter regulation, reduction of excitatory toxicity, and early neuronal development. Drugs targeting mGluR7 (mGluR7 agonists, antagonists, and allosteric modulators) may be among the most promising agents for the treatment of CNS disorders, such as psychiatric disorders, neurodegenerative diseases, and neurodevelopmental impairments, though these potential therapies are at early stages and the data are still limited. In this review, we summarized the structure and function of mGluR7 and discussed recent progress on mGluR7 agonists and antagonists. A deeper understanding of mGluR7 will contribute to uncovering the molecular mechanisms of neuroprotection and providing a theoretical basis for the formulation of therapeutic strategies.

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.