Mixed Reality-Based Smart Occupational Therapy Personalized Protocol for Cerebellar Ataxic Patients.

Background: Occupational therapy (OT) is an essential component of patient care, and it is especially beneficial if focused on meaningful activities. For ataxic patients, traditional procedures are currently the most efficient, although without specific guidelines and suggestions for virtual reality integration. In this context, this study proposes Hybrid Smart Rehabilitation (HSR) based on mixed reality (MR) as an aid in overcoming limitations of the traditional OT procedures.

Methods: MR-HSR is designed specifically for ataxic patients and developed in Unity with the Holographic Remoting setting for run-time intervention on the scene. The subject reaches a book and grabs it with their hand inside a holographic guide with audio-visive feedback. Hand trajectories acquired from eight ataxic patients and eight healthy subjects were compared and new variables were analyzed to evaluate the performance. The Trust in Automation questionnaire was submitted to assess the opinion of the patients.

Results: Patients confirmed their trust in the developer and in the improvement that this system can bring to their rehabilitation. The "total time" and "sway area" of the trajectory were statistically significant and, together with the deviation of the trajectory from the main axis of the guide, although not statistically significant, made it possible to build a classifier.

Conclusions: The patient-specific MR-HSR can be considered as an integrative tool for assessing the subject's condition by analyzing new quantitative variables which, if matched to the Scale for the Assessment and Rating of Ataxia (SARA), could be the basis of a new index to assess the progressiveness of ataxia.