脑脊液神经丝光链区分不同进展速度(RoP)的阿尔茨海默病患者:初步研究。

IF 2.7 3区 医学 Q3 NEUROSCIENCES
Valeria Blandino, Tiziana Colletti, Paolo Ribisi, Domenico Tarantino, Viviana Mosca, Luisa Agnello, Marcello Ciaccio, Tommaso Piccoli
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引用次数: 0

摘要

阿尔茨海默病(AD)是最常见的神经退行性疾病,也是导致痴呆症的主要原因。临床医生面临的一大挑战是在诊断早期准确评估疾病进展率(RoP),这对患者管理和临床试验分层至关重要。本研究评估了脑脊液生物标志物-Aβ42、t-Tau、pTau、神经粒蛋白(Ng)和神经丝轻链(NF-L)在预测AD诊断时的RoP中的作用。我们纳入了 56 名注意力缺失症患者,并在诊断时和六个月的随访期间使用 MMSE 评分监测认知功能障碍。根据这些评估结果计算出RoP评分。我们的相关分析表明,RoP 与 pTau、Aβ42/Ng 比值和 NF-L 水平之间存在显著关联。根据中位 RoP 值将患者分为低度至中度(L-M:2)组,与 L-M 组相比,U-M 组患者的 CSF NF-L 水平明显更高。逻辑回归分析进一步表明,CSF NF-L 水平升高可预测更快的 RoP。这些发现凸显了 CSF NF-L 作为 AD 疾病快速进展的预后生物标志物的潜力。CSF NF-L可以识别有认知能力加速衰退风险的患者,从而大大加强早期干预策略,改善临床环境中的患者管理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cerebrospinal Fluid Neurofilaments Light-Chain Differentiate Patients Affected by Alzheimer's Disease with Different Rate of Progression (RoP): A Preliminary Study.

Alzheimer's disease (AD) is the most common neurodegenerative disorder and a leading cause of dementia. One major challenge for clinicians is accurately assessing the rate of disease progression (RoP) early in the diagnostic process, which is crucial for patient management and clinical trial stratification. This study evaluated the role of cerebrospinal fluid biomarkers-Aβ42, t-Tau, pTau, Neurogranin (Ng), and Neurofilament light-chain (NF-L)-in predicting RoP at the time of AD diagnosis. We included 56 AD patients and monitored cognitive impairment using MMSE scores at diagnosis and during six-month follow-up visits. RoP scores were calculated based on these assessments. Our correlation analyses revealed significant associations between RoP and pTau, Aβ42/Ng ratio, and NF-L levels. When patients were stratified by median RoP values into low-to-moderate (L-M: <2) and upper-moderate (U-M: >2) groups, those in the U-M group had notably higher CSF NF-L levels compared to the L-M group. Logistic regression analysis further demonstrated that elevated CSF NF-L levels were predictive of a faster RoP. These findings highlight the potential of CSF NF-L as a prognostic biomarker for rapid disease progression in AD. By identifying patients at risk for accelerated cognitive decline, CSF NF-L could significantly enhance early intervention strategies and improve patient management in clinical settings.

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来源期刊
Brain Sciences
Brain Sciences Neuroscience-General Neuroscience
CiteScore
4.80
自引率
9.10%
发文量
1472
审稿时长
18.71 days
期刊介绍: Brain Sciences (ISSN 2076-3425) is a peer-reviewed scientific journal that publishes original articles, critical reviews, research notes and short communications in the areas of cognitive neuroscience, developmental neuroscience, molecular and cellular neuroscience, neural engineering, neuroimaging, neurolinguistics, neuropathy, systems neuroscience, and theoretical and computational neuroscience. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.
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