淀粉样β肽在氧化应激和炎症中的双重作用:揭示阿尔茨海默病病因学中的联系

IF 6 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Hugo Fanlo-Ucar, Pol Picón-Pagès, Víctor Herrera-Fernández, Gerard Ill-Raga, Francisco J Muñoz
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引用次数: 0

摘要

阿尔茨海默病(AD)是一种进行性神经退行性疾病,目前是全球第七大死亡原因。其特征是淀粉样β肽(Aβ)在细胞外聚集成低聚物和纤维,导致突触毒性和神经元死亡。Aβ 具有促进氧化应激和炎症的双重作用。本综述旨在揭示这些过程之间错综复杂的联系,以及它们对注意力缺失症进展的贡献。综述深入探讨了 AD 中的氧化应激,重点关注金属、线粒体功能障碍和生物大分子氧化的参与。此外,还讨论了硝基氧化应激这一截然不同但又相互重叠的概念,详细阐述了一氧化氮、线粒体扰动的作用及其对 Aβ 生成和神经毒性的累积影响。通过星形胶质细胞和小胶质细胞的功能研究了炎症,阐明了它们对Aβ的反应及其对AD大脑氧化应激的贡献。血脑屏障和少突胶质细胞也被纳入了AD病理生理学的范畴。我们还回顾了当前的诊断方法和新出现的治疗策略,这些策略旨在减轻氧化应激和炎症,从而为阻止或延缓AD进展提供潜在的治疗方法。这篇全面的综述强调了 Aβ 在连接氧化应激和炎症方面的关键作用,从而加深了我们对注意力缺失症的理解,并为未来的研究和治疗范例提供了参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Dual Role of Amyloid Beta-Peptide in Oxidative Stress and Inflammation: Unveiling Their Connections in Alzheimer's Disease Etiopathology.

Alzheimer's disease (AD) is a progressive neurodegenerative disease, and it is currently the seventh leading cause of death worldwide. It is characterized by the extracellular aggregation of the amyloid β-peptide (Aβ) into oligomers and fibrils that cause synaptotoxicity and neuronal death. Aβ exhibits a dual role in promoting oxidative stress and inflammation. This review aims to unravel the intricate connection between these processes and their contribution to AD progression. The review delves into oxidative stress in AD, focusing on the involvement of metals, mitochondrial dysfunction, and biomolecule oxidation. The distinct yet overlapping concept of nitro-oxidative stress is also discussed, detailing the roles of nitric oxide, mitochondrial perturbations, and their cumulative impact on Aβ production and neurotoxicity. Inflammation is examined through astroglia and microglia function, elucidating their response to Aβ and their contribution to oxidative stress within the AD brain. The blood-brain barrier and oligodendrocytes are also considered in the context of AD pathophysiology. We also review current diagnostic methodologies and emerging therapeutic strategies aimed at mitigating oxidative stress and inflammation, thereby offering potential treatments for halting or slowing AD progression. This comprehensive synthesis underscores the pivotal role of Aβ in bridging oxidative stress and inflammation, advancing our understanding of AD and informing future research and treatment paradigms.

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来源期刊
Antioxidants
Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology
CiteScore
10.60
自引率
11.40%
发文量
2123
审稿时长
16.3 days
期刊介绍: Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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