囊性肾病中的活性氧。

IF 6 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Sanat Subhash, Sonya Vijayvargiya, Aetan Parmar, Jazlyn Sandhu, Jabrina Simmons, Rupesh Raina
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引用次数: 0

摘要

多囊肾(PKD)是一种罕见但严重的肾病,对全球急性和慢性病患者的护理具有重大影响。氧化应激和活性氧(ROS)可显著改变其病理生理学、临床结果和治疗,导致高血压、慢性肾病和肾衰竭等不良后果。ROS 引起的炎症和现有的囊肿会促进 ROS 的产生和积累,加剧肾脏损伤、促纤维化信号级联和间质纤维化。氧化应激和 ROS 的早期识别和预防有助于减少囊性肾脏疾病的进展和改善患者的纵向预后。为了规范临床实践和改善患者预后,必须加强对生物标志物、氧化应激病理生理学和新型治疗干预措施的研究,同时制定综合指南,确定评估、监测和干预囊性肾脏病患者氧化应激的方法。人工智能(AI)、基因编辑和基因组测序的整合可进一步改善囊性肾脏病的早期检测和管理,减轻患者的不良预后。在这篇综述中,我们旨在全面评估 ROS 在囊性肾脏病中的多因素作用,分析其病理生理学、临床结果、治疗干预、临床试验、动物模型以及患者护理的未来方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Reactive Oxygen Species in Cystic Kidney Disease.

Polycystic kidney disease (PKD) is a rare but significant renal condition with major implications for global acute and chronic patient care. Oxidative stress and reactive oxygen species (ROS) can significantly alter its pathophysiology, clinical outcomes, and treatment, contributing to negative outcomes, including hypertension, chronic kidney disease, and kidney failure. Inflammation from ROS and existing cysts propagate the generation and accumulation of ROS, exacerbating kidney injury, pro-fibrotic signaling cascades, and interstitial fibrosis. Early identification and prevention of oxidative stress and ROS can contribute to reduced cystic kidney disease progression and improved longitudinal patient outcomes. Increased research regarding biomarkers, the pathophysiology of oxidative stress, and novel therapeutic interventions alongside the creation of comprehensive guidelines establishing methods of assessment, monitoring, and intervention for oxidative stress in cystic kidney disease patients is imperative to standardize clinical practice and improve patient outcomes. The integration of artificial intelligence (AI), genetic editing, and genome sequencing could further improve the early detection and management of cystic kidney disease and mitigate adverse patient outcomes. In this review, we aim to comprehensively assess the multifactorial role of ROS in cystic kidney disease, analyzing its pathophysiology, clinical outcomes, treatment interventions, clinical trials, animal models, and future directions for patient care.

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来源期刊
Antioxidants
Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology
CiteScore
10.60
自引率
11.40%
发文量
2123
审稿时长
16.3 days
期刊介绍: Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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