评估膳食酸负荷在妊娠期高血压疾病发展中的作用:通过前瞻性队列分析发现关联。

IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS
Fatemeh Safarpour, Mehrnoosh Shafaatdoost, Reza Naeimi, Ashraf Moini, Reihaneh Pirjani, Zahra Basirat, Azar Mardi-Mamaghani, Mahnaz Esmaeili, Mahroo Rezaeinejad, Mahdi Sepidarkish
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引用次数: 0

摘要

背景:妊娠高血压疾病(HDPs)是妊娠期常见的并发症,影响全球5%至15%的妊娠。一些研究表明,坚持高酸负荷饮食会增加妊娠高血压疾病的风险。本研究调查了膳食酸负荷(DAL)与子痫前期、慢性高血压(HTN)和妊娠高血压(GHTN)发病率之间的关系:方法:选取年龄在 18 至 45 岁之间、处于妊娠头三个月的孕妇,对其进行随访直至分娩。采用 168 题半定量食物频率问卷(FFQ)对饮食进行评估。在计算出 DAL 分数后,利用增强广义模型估算出的倾向分数的逆概率权重,得出调整潜在混杂因素后的因果风险比 (RR):在 1856 名妇女中,有 92 人(4.95%)罹患子痫前期。潜在肾酸负荷(PRAL)评分范围为-16.14至0.58,而净内源性产酸(NEAP)评分范围为34.61至50.15。多变量分析显示,与参照组(Q2)相比,PRAL 的第一四分位数(aRR:1.87,95% CI:1.01,3.49,p = 0.048)和第三四分位数(aRR:2.01,95% CI:1.07,3.81,p = 0.030)与子痫前期之间存在显著关联。在连续性分析中未发现明显的线性关系。就慢性高血压而言,在第一组(aRR:2.56,95% CI:1.21,5.42,p = 0.014)和第四组(aRR:4.79,95% CI:2.37,9.71,p 结论)中观察到了明显的相关性:PRAL和NEAP显示的DAL极值与子痫前期、慢性高血压和GHTN的风险增加有关,尤其是在最高和最低四分位数。这些发现凸显了 DAL 对 HDPs 的潜在影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assessing the role of dietary acid load in the development of hypertensive disorders during pregnancy: uncovering the association through prospective cohort analysis.

Background: Hypertensive disorders of pregnancy (HDPs) are common complications encountered in pregnancy that affect between 5% and 15% of pregnancies worldwide. Some studies have associated adherence to a diet with a high acid load with an increased risk of HDPs. This study investigates the association between Dietary Acid Load (DAL) and the incidence of preeclampsia, chronic hypertension (HTN), and gestational hypertension (GHTN).

Methods: Pregnant women aged 18 to 45 in the first trimester of pregnancy were selected and followed up until delivery. Diet was evaluated using a 168-question semi-quantitative food frequency questionnaire (FFQ). After calculating the DAL score, the inverse probability weight of the propensity scores, estimated from augmented generalized models, was used to obtain a causal risk ratio (RR) adjusted for potential confounders.

Results: Out of 1,856 women, 92 (4.95%) developed preeclampsia. The potential renal acid load (PRAL) score ranged from - 16.14 to 0.58, while the net endogenous acid production (NEAP) score ranged from 34.61 to 50.15. Multivariable analysis revealed a significant association between PRAL and preeclampsia in the first (aRR: 1.87, 95% CI: 1.01, 3.49, p = 0.048) and third (aRR: 2.01, 95% CI: 1.07, 3.81, p = 0.030) quartiles compared to the reference group (Q2). No significant linear association was found in continuous analyses. For chronic HTN, significant associations were observed in the first (aRR: 2.56, 95% CI: 1.21, 5.42, p = 0.014) and fourth (aRR: 4.79, 95% CI: 2.37, 9.71, p < 0.001) PRAL quartiles, with similar findings for NEAP. Continuous analysis showed a significant linear association between both PRAL and NEAP scores and chronic HTN. Regarding GHTN, significant associations were found in the first (aRR: 1.48, 95% CI: 1.02, 2.16, p = 0.041) and fourth (aRR: 1.88, 95% CI: 1.31, 2.70, p = 0.001) PRAL quartiles, and in Q4 for NEAP (aRR: 1.56, 95% CI: 1.10, 2.21, p = 0.012), with no significant linear association in continuous analysis.

Conclusion: Extremes in DAL, as indicated by PRAL and NEAP, are associated with an increased risk of preeclampsia, chronic HTN, and GHTN, particularly in the highest and lowest quartiles. These findings highlight the potential impact of DAL on HDPs.

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来源期刊
Nutrition Journal
Nutrition Journal NUTRITION & DIETETICS-
CiteScore
9.80
自引率
0.00%
发文量
68
审稿时长
4-8 weeks
期刊介绍: Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered. Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies. In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.
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