钙强化对负载槲皮素的玉米蛋白/精氨酸-槲皮素纳米颗粒的稳定性、生物利用度和生物活性的影响

IF 3.3 2区农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY

Journal of the Science of Food and Agriculture Pub Date : 2025-02-01 Epub Date: 2024-10-12 DOI:10.1002/jsfa.13954

Wan Li, Xiaoqing Zhu, Yingchun Zhou, Yuan Jiang, Jingying Feng, David Julian McClements, Kun Hu

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引用次数: 0

摘要

背景：阳离子钙离子可交联阴离子海藻酸盐和果胶分子。据推测，钙交联将提高由藻酸盐-果胶外壳包裹的玉米蛋白核心组成的生物聚合物纳米颗粒的稳定性和功能性。因此，研究了钙离子添加对槲皮素负载的玉米蛋白/海藻酸pectin纳米粒子的结构、理化和胃肠道特性的影响：结果：当钙离子浓度为 9 mmol/L 或更低时，纳米颗粒仍能保持稳定的聚集状态，但当钙离子浓度更高时，纳米颗粒就会聚集和沉淀。即使在 NaCl 浓度高达 1.4 molL-1 时，钙离子的强化也能提高颗粒的分散稳定性。钙离子的存在还减少了槲皮素在模拟胃肠道消化早期阶段的释放，但增加了其在后期阶段的释放。钙强化纳米粒子在消化后的槲皮素释放量相对较高（56.1%），从而提高了细胞内的抗氧化活性。对大鼠口服封装槲皮素后的药代动力学进行了测定。钙离子增强纳米粒子在大鼠血浆中的槲皮素最大浓度（Cmax）比未增强纳米粒子高 6.1%；半衰期（t1/2）延长了 17.5%，平均滞留时间（MRT）延长了 10.0%（P 结论：钙离子增强纳米粒子在大鼠血浆中的槲皮素最大浓度（Cmax）比未增强纳米粒子高 6.1%，半衰期（t1/2）延长了 17.5%，平均滞留时间（MRT）延长了 10.0%：这些结果表明，添加钙离子提高了营养保健品负载生物聚合物纳米粒子的性能和生物利用率。这可能会应用于食品和饮料行业。© 2024 化学工业协会。

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Impact of calcium-reinforcement on stability, bioavailability, and bioactivity of quercetin-loaded zein/alginate-pectin nanoparticles.

Background: Cationic calcium ions can crosslink anionic alginate and pectin molecules. It was hypothesized that calcium crosslinking would improve the stability and functionality of biopolymer nanoparticles consisting of zein cores coated by alginate-pectin shells. The effects of calcium ion addition on the structural, physicochemical, and gastrointestinal properties of quercetin-loaded zein/alginate-pectin nanoparticles were therefore investigated.

Results: The nanoparticles remained stable to aggregation at calcium ion concentrations of 9 mmol/L or less but aggregated and sedimented at higher concentrations. Calcium ion reinforcement increased the particle dispersion stability even at NaCl concentrations up to 1.4 molL^-1. The presence of the calcium ions also reduced quercetin release during the early stages of simulated gastrointestinal digestion but increased its release during the later stages. The relatively high release (56.1%) of quercetin from the calcium-reinforced nanoparticles after digestion resulted in higher intracellular antioxidant activities. The pharmacokinetics of the encapsulated quercetin was measured after its oral administration to rats. The maximal concentration (C_max) of quercetin in rat plasma for calcium-reinforced nanoparticles was 6.1% higher than non-reinforced nanoparticles; the half-life (t_1/2) increased by 17.5%, and the mean retention time (MRT) was 10.0% higher (P < 0.05).

Conclusion: These results suggest that calcium ion addition improved the performance and bioavailability of nutraceutical-loaded biopolymer nanoparticles. This might find application in the food and beverage industry. © 2024 Society of Chemical Industry.

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来源期刊

Journal of the Science of Food and Agriculture 工程技术-农业综合

CiteScore

8.10

自引率

4.90%

发文量

634

审稿时长

3.1 months

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