青春期与睡眠和大脑网络组织相互作用,可预测心理健康。

IF 2.4 3区 医学 Q3 NEUROSCIENCES
Frontiers in Human Neuroscience Pub Date : 2024-09-27 eCollection Date: 2024-01-01 DOI:10.3389/fnhum.2024.1379945
Mackenzie E Mitchell, Tehila Nugiel
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引用次数: 0

摘要

简介伴随着青春期的发育,向青春期过渡会增加睡眠障碍和心理健康问题的风险。据报道,重叠的大规模大脑网络的功能连接,如默认模式和背侧注意力网络之间的连接增加,与睡眠和心理健康问题都有关系。阐明青春期发育是否与睡眠障碍和大脑功能网络相互作用以预测心理健康,可为改善针对青少年睡眠障碍的干预措施的时机和设计提供信息:为了研究青春期状态和节奏与睡眠障碍之间的关系,以及睡眠障碍与心理健康问题之间的关系,我们利用了青少年大脑和认知发展(ABCD)研究(N ~ 3,000-10,000 人)中的大量 10-14 岁儿童样本。我们使用图式理论工具来探究青春期发育如何同时与睡眠障碍和大脑网络组织相互作用,从而预测心理健康问题:结果:我们发现,青春期发育状况(而非青春期发育节奏)可预测睡眠障碍;然而,青春期发育状况和青春期发育节奏与睡眠障碍相互作用,可预测心理健康问题,并与睡眠和大脑网络组织三者相互作用,可预测心理健康问题:总之,这项研究表明,较晚的青春期状况和较慢的节奏是睡眠障碍、大脑组织和心理健康问题之间联系最紧密的风险因素。此外,我们的研究结果还说明了考虑围绕复杂行为和临床综合症(包括内化和外化障碍)的各种因素之间相互作用的重要性,并为有针对性的干预措施提供了新的背景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Puberty interacts with sleep and brain network organization to predict mental health.

Introduction: Along with pubertal development, the transition to adolescence brings about increased risk for sleep disturbances and mental health problems. Functional connectivity of overlapping large-scale brain networks, such as increased connectivity between the default mode and dorsal attention networks, has been reported to relate to both sleep and mental health problems. Clarifying whether pubertal development interacts with sleep disturbances and functional brain networks to predict mental health may provide information to improve the timing and design of interventions targeting sleep disturbances in adolescents.

Methods: To examine how pubertal status and tempo relate to sleep disturbances and shape the relationship between sleep disturbances and mental health problems, we harnessed a large sample of children aged 10-14 years from the Adolescent Brain and Cognitive Development (ABCD) Study (N ~ 3,000-10,000). We used graph theoretical tools to probe how pubertal development concurrently interacts with sleep disturbances and brain network organization to predict mental health problems.

Results: We found that advanced pubertal status, but not pubertal tempo, predicted sleep disturbances; however, both pubertal status and tempo interact with sleep disturbances to predict mental health problems and engage in three-way interactions with sleep and brain network organization to predict mental health problems.

Discussion: Overall, this work suggests that less advanced pubertal status and slower tempo are risk factors for the strongest links between sleep disturbances, brain organization, and mental health problems. Further, our findings speak to the importance of accounting for interactions in the constellation of factors that surround complex behavioral and clinical syndromes, here internalizing and externalizing disorders, and provide new context to consider for targeted interventions.

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来源期刊
Frontiers in Human Neuroscience
Frontiers in Human Neuroscience 医学-神经科学
CiteScore
4.70
自引率
6.90%
发文量
830
审稿时长
2-4 weeks
期刊介绍: Frontiers in Human Neuroscience is a first-tier electronic journal devoted to understanding the brain mechanisms supporting cognitive and social behavior in humans, and how these mechanisms might be altered in disease states. The last 25 years have seen an explosive growth in both the methods and the theoretical constructs available to study the human brain. Advances in electrophysiological, neuroimaging, neuropsychological, psychophysical, neuropharmacological and computational approaches have provided key insights into the mechanisms of a broad range of human behaviors in both health and disease. Work in human neuroscience ranges from the cognitive domain, including areas such as memory, attention, language and perception to the social domain, with this last subject addressing topics, such as interpersonal interactions, social discourse and emotional regulation. How these processes unfold during development, mature in adulthood and often decline in aging, and how they are altered in a host of developmental, neurological and psychiatric disorders, has become increasingly amenable to human neuroscience research approaches. Work in human neuroscience has influenced many areas of inquiry ranging from social and cognitive psychology to economics, law and public policy. Accordingly, our journal will provide a forum for human research spanning all areas of human cognitive, social, developmental and translational neuroscience using any research approach.
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