Veridiana Domingues, João V Cavalari, Kamila Grandolfi, Andreo F Aguiar, Sergio M Borghi, Juliano Casonatto
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Resting blood pressure was measured after a 20-min period of comfortable seating in a calm environment. Both groups underwent 40 min of treadmill running/walking at an intensity of 60-70% of their reserve heart rate, 120 min after ingesting the substances. Ambulatory blood pressure monitoring was employed to measure blood pressure over 24 h.</p><p><strong>Results: </strong>No significant differences in systolic blood pressure values were observed between the CM and PLA groups at rest, during wakefulness, sleep, or over a 24-h period. However, CM exhibited a significant reduction in diastolic blood pressure in several metrics: delta 24 h (-14 mmHg vs -6 mmHg, <i>p</i> = 0.047), delta wakefulness (-12 mmHg vs -4 mmHg, <i>p</i> = 0.024), percent delta 24 h (-16% vs -6%, <i>p</i> = 0.024), and percent delta wakefulness (-14% vs -4%, <i>p</i> = 0.013). No significant differences were found between CM and PLA in terms of systolic and diastolic nocturnal absolute reductions (-13 mmHg vs -12 mmHg, <i>p</i> = 0.808, and -13 mmHg vs -8 mmHg, <i>p</i> = 0.273, respectively) or nocturnal percentage decrease (-9.9% vs -9.4%, <i>p</i> = 0.844, and -15.3% vs -11.7%, <i>p</i> = 0.399, respectively).</p><p><strong>Conclusions: </strong>The study found no significant changes in the post-exercise nocturnal blood pressure dip following a single dose of CM supplementation. However, a notable reduction in diastolic blood pressure was observed during the waking period and over the average 24-h monitoring period.</p><p><strong>Clinical trial registry number and website: </strong>ClinicalTrials.gov platform (NCT03378596).</p>","PeriodicalId":15646,"journal":{"name":"Journal of Dietary Supplements","volume":" ","pages":"868-880"},"PeriodicalIF":2.3000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Acute Effects of Citrulline Malate Supplementation on Nocturnal Blood Pressure Dipping After Exercise in Hypertensive Patients: A Randomized, Placebo-Controlled Trial.\",\"authors\":\"Veridiana Domingues, João V Cavalari, Kamila Grandolfi, Andreo F Aguiar, Sergio M Borghi, Juliano Casonatto\",\"doi\":\"10.1080/19390211.2024.2414052\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Citrulline malate (CM), especially when used in conjunction with physical exercise, has demonstrated potential as a non-pharmacological adjunct in the management of hypertension. Nevertheless, its impact on nocturnal blood pressure dipping remains unexplored.</p><p><strong>Objective: </strong>Evaluate the impact of a single dose of CM on nocturnal blood pressure dipping after exercise in hypertensive individuals.</p><p><strong>Methods: </strong>In a double-blind, placebo-controlled, parallel-group clinical trial, twenty hypertensive adults (55 ± 16 years) were randomly assigned to either a CM (6 g) or placebo (6 g of corn starch) group (PLA). Resting blood pressure was measured after a 20-min period of comfortable seating in a calm environment. Both groups underwent 40 min of treadmill running/walking at an intensity of 60-70% of their reserve heart rate, 120 min after ingesting the substances. Ambulatory blood pressure monitoring was employed to measure blood pressure over 24 h.</p><p><strong>Results: </strong>No significant differences in systolic blood pressure values were observed between the CM and PLA groups at rest, during wakefulness, sleep, or over a 24-h period. However, CM exhibited a significant reduction in diastolic blood pressure in several metrics: delta 24 h (-14 mmHg vs -6 mmHg, <i>p</i> = 0.047), delta wakefulness (-12 mmHg vs -4 mmHg, <i>p</i> = 0.024), percent delta 24 h (-16% vs -6%, <i>p</i> = 0.024), and percent delta wakefulness (-14% vs -4%, <i>p</i> = 0.013). No significant differences were found between CM and PLA in terms of systolic and diastolic nocturnal absolute reductions (-13 mmHg vs -12 mmHg, <i>p</i> = 0.808, and -13 mmHg vs -8 mmHg, <i>p</i> = 0.273, respectively) or nocturnal percentage decrease (-9.9% vs -9.4%, <i>p</i> = 0.844, and -15.3% vs -11.7%, <i>p</i> = 0.399, respectively).</p><p><strong>Conclusions: </strong>The study found no significant changes in the post-exercise nocturnal blood pressure dip following a single dose of CM supplementation. 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引用次数: 0
摘要
背景：苹果酸瓜氨酸（CM），尤其是与体育锻炼结合使用时，已被证明具有作为非药物辅助治疗高血压的潜力。然而，它对夜间血压下降的影响仍有待探索：评估单剂量中药对高血压患者运动后夜间血压下降的影响：在一项双盲、安慰剂对照、平行组临床试验中，20 名高血压成人（55 ± 16 岁）被随机分配到中药组（6 克）或安慰剂组（6 克玉米淀粉）（PLA）。在安静环境中舒适就座 20 分钟后测量静息血压。在摄入药物 120 分钟后，两组人都在跑步机上以储备心率 60-70% 的强度跑步/散步 40 分钟。使用动态血压监测仪测量 24 小时内的血压：结果：在休息时、清醒时、睡眠时或 24 小时内，CM 组和 PLA 组的收缩压值均无明显差异。然而，CM 组的舒张压在以下几个指标上有明显降低：24 小时△值（-14 mmHg vs -6 mmHg，p = 0.047）、觉醒△值（-12 mmHg vs -4 mmHg，p = 0.024）、24 小时△值百分比（-16% vs -6%，p = 0.024）和觉醒△值百分比（-14% vs -4%，p = 0.013）。在收缩压和舒张压夜间绝对降低（分别为-13 mmHg vs -12 mmHg，p = 0.808和-13 mmHg vs -8mmHg，p = 0.273）或夜间百分比降低（分别为-9.9% vs -9.4%，p = 0.844和-15.3% vs -11.7%，p = 0.399）方面，CM和PLA之间没有发现明显差异：该研究发现，补充单剂量中药后，运动后夜间血压下降没有明显变化。然而，在清醒期间和平均 24 小时的监测期间，舒张压明显下降：临床试验登记号和网站：ClinicalTrials.gov 平台（NCT03378596）。
Acute Effects of Citrulline Malate Supplementation on Nocturnal Blood Pressure Dipping After Exercise in Hypertensive Patients: A Randomized, Placebo-Controlled Trial.
Background: Citrulline malate (CM), especially when used in conjunction with physical exercise, has demonstrated potential as a non-pharmacological adjunct in the management of hypertension. Nevertheless, its impact on nocturnal blood pressure dipping remains unexplored.
Objective: Evaluate the impact of a single dose of CM on nocturnal blood pressure dipping after exercise in hypertensive individuals.
Methods: In a double-blind, placebo-controlled, parallel-group clinical trial, twenty hypertensive adults (55 ± 16 years) were randomly assigned to either a CM (6 g) or placebo (6 g of corn starch) group (PLA). Resting blood pressure was measured after a 20-min period of comfortable seating in a calm environment. Both groups underwent 40 min of treadmill running/walking at an intensity of 60-70% of their reserve heart rate, 120 min after ingesting the substances. Ambulatory blood pressure monitoring was employed to measure blood pressure over 24 h.
Results: No significant differences in systolic blood pressure values were observed between the CM and PLA groups at rest, during wakefulness, sleep, or over a 24-h period. However, CM exhibited a significant reduction in diastolic blood pressure in several metrics: delta 24 h (-14 mmHg vs -6 mmHg, p = 0.047), delta wakefulness (-12 mmHg vs -4 mmHg, p = 0.024), percent delta 24 h (-16% vs -6%, p = 0.024), and percent delta wakefulness (-14% vs -4%, p = 0.013). No significant differences were found between CM and PLA in terms of systolic and diastolic nocturnal absolute reductions (-13 mmHg vs -12 mmHg, p = 0.808, and -13 mmHg vs -8 mmHg, p = 0.273, respectively) or nocturnal percentage decrease (-9.9% vs -9.4%, p = 0.844, and -15.3% vs -11.7%, p = 0.399, respectively).
Conclusions: The study found no significant changes in the post-exercise nocturnal blood pressure dip following a single dose of CM supplementation. However, a notable reduction in diastolic blood pressure was observed during the waking period and over the average 24-h monitoring period.
Clinical trial registry number and website: ClinicalTrials.gov platform (NCT03378596).
期刊介绍：
The Journal of Dietary Supplements (formerly the Journal of Nutraceuticals, Functional & Medical Foods) has been retitled to reflect the bold departure from a traditional scientific journal presentation to a leading voice for anyone with a stake in dietary supplements. The journal addresses important issues that meet the broad range of interests from researchers, regulators, marketers, educators, and health professionals from academic, governmental, industry, healthcare, public health, and consumer education sectors. This vital tool not only presents scientific information but interprets it - helping you more readily pass it on to your students, patients, clients, or company.
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