益生菌 Lactiplantibacillus plantarum subsp. plantarum Dad-13 通过产生短链脂肪酸和调节炎症细胞因子缓解 2,4,6-Trinitrobenzene Sulfonic Acid 诱发的结肠炎。

IF 1.6 Q3 FOOD SCIENCE & TECHNOLOGY
Rimba Bunga Pertiwi, Yosinta Christie Setiabudi, Yunika Mayangsari, Dian Anggraini Suroto, Endang Sutriswati Rahayu
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引用次数: 0

摘要

炎症性肠病(IBD)的发生与炎症损伤和菌群失调密切相关。最近,益生菌正被越来越多地用于改善肠道健康。基于益生菌的疗法可以通过恢复胃肠道微生物群的平衡、减少肠道炎症和增加短链脂肪酸(SCFAs)的浓度来预防 IBD。本研究旨在探讨植物乳杆菌亚种(Lactiplantibacillus plantarum subsp. plantarum Dad-13)对 2,4,6-三硝基苯磺酸(TNBS)诱导的 BALB/c 小鼠结肠炎的保护作用。结果表明,补充剂量为 107 或 109 CFU/mL 的益生菌 Dad-13 可改善 IBD 的临床症状,并促进 SCFAs(尤其是丙酸盐和丁酸盐)的产生。此外,补充益生菌Dad-13还能显著降低促炎细胞因子[肿瘤坏死因子-α、白细胞介素(IL)-6和IL-1β]的水平,并显著提高抗炎细胞因子(IL-10)的水平。这些研究结果表明,植物乳杆菌 Dad-13 可通过调节 SCFA 的产生和炎症细胞因子,有效预防 TNBS 引起的结肠炎。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Probiotic Lactiplantibacillus plantarum subsp. plantarum Dad-13 Alleviates 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Colitis Through Short-Chain Fatty Acid Production and Inflammatory Cytokine Regulation.

The development of inflammatory bowel disease (IBD) is closely linked to inflammatory damage and dysbiosis. Recently, probiotics are being increasingly used to improve intestinal health. Probiotic-based therapies can prevent IBD by restoring the balance of gastrointestinal microbiota, reducing gut inflammation, and increasing the concentration of short-chain fatty acids (SCFAs). The present study aimed to investigate the protective effects of Lactiplantibacillus plantarum subsp. plantarum Dad-13, a novel probiotic strain derived from dadih (Indonesian curd from buffalo milk), on 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in BALB/c mice. The results showed that probiotic Dad-13 supplementation at a dose of 107 or 109 CFU/mL improved the clinical symptoms of IBD and enhanced the production of SCFAs, particularly propionate and butyrate. Moreover, probiotic Dad-13 supplementation significantly decreased the levels of pro-inflammatory cytokines [tumor necrosis factor-α, interleukin (IL)-6, and IL-1β] and significantly increased the levels of anti-inflammatory cytokines (IL-10). These findings show that L. plantarum Dad-13 can effectively prevent TNBS-induced colitis by modulating SCFA production and inflammatory cytokines.

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来源期刊
Preventive Nutrition and Food Science
Preventive Nutrition and Food Science Agricultural and Biological Sciences-Food Science
CiteScore
3.40
自引率
0.00%
发文量
35
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