沿 CA1 横轴的相似 Theta 相位编码动力学

IF 2.4 3区 医学 Q3 NEUROSCIENCES
Hippocampus Pub Date : 2024-10-05 DOI:10.1002/hipo.23641
Aditi Bishnoi, Sachin S. Deshmukh
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引用次数: 0

摘要

从内侧皮层到海马 CA1 区的地形投射模式导致了一种假说,即近端 CA1(pCA1,更靠近 CA2)比远端 CA1(dCA1,更靠近子网)具有更强的空间选择性。虽然早期的研究显示有证据支持这一假说,但我们最近的研究表明,这种差异并非在所有实验条件下都成立。在一个复杂的环境中,圆形轨道上有不同的局部纹理线索和全局视觉线索,pCA1 和 dCA1 显示出相似的空间选择性。与空间选择性差异相关的是,早期的研究还显示 pCA1 和 dCA1 神经元之间的θ相位编码动态存在差异。在这里,我们发现在 pCA1 和 dCA1 神经元具有同等空间选择性的实验条件下,这两个区域的神经元之间的 Theta 相位编码动态并无差异。这些发现挑战了 dCA1 在空间选择性和 theta 调制方面天生不如 pCA1 的既有观点,并建议进行进一步的实验,以了解 Theta 介导的 CA1 亚网络对空间表征的激活。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparable Theta Phase Coding Dynamics Along the Transverse Axis of CA1

Topographical projection patterns from the entorhinal cortex to area CA1 of the hippocampus have led to a hypothesis that proximal CA1 (pCA1, closer to CA2) is spatially more selective than distal CA1 (dCA1, closer to the subiculum). While earlier studies have shown evidence supporting this hypothesis, we recently showed that this difference does not hold true under all experimental conditions. In a complex environment with distinct local texture cues on a circular track and global visual cues, pCA1 and dCA1 display comparable spatial selectivity. Correlated with the spatial selectivity differences, the earlier studies also showed differences in theta phase coding dynamics between pCA1 and dCA1 neurons. Here we show that there are no differences in theta phase coding dynamics between neurons in these two regions under the experimental conditions where pCA1 and dCA1 neurons are equally spatially selective. These findings challenge the established notion of dCA1 being inherently less spatially selective and theta modulated than pCA1 and suggest further experiments to understand theta-mediated activation of the CA1 sub-networks to represent space.

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来源期刊
Hippocampus
Hippocampus 医学-神经科学
CiteScore
5.80
自引率
5.70%
发文量
79
审稿时长
3-8 weeks
期刊介绍: Hippocampus provides a forum for the exchange of current information between investigators interested in the neurobiology of the hippocampal formation and related structures. While the relationships of submitted papers to the hippocampal formation will be evaluated liberally, the substance of appropriate papers should deal with the hippocampal formation per se or with the interaction between the hippocampal formation and other brain regions. The scope of Hippocampus is wide: single and multidisciplinary experimental studies from all fields of basic science, theoretical papers, papers dealing with hippocampal preparations as models for understanding the central nervous system, and clinical studies will be considered for publication. The Editor especially encourages the submission of papers that contribute to a functional understanding of the hippocampal formation.
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